Long noncoding RNAs in aging and age-related diseases

Highlights • Aging process involves decline in biological functions over the time. • Pervasive transcription of lncRNAs in mammals regulates various cellular processes. • LncRNAs could affect aging via chromatin modulation and telomere maintenance. • Various p53 regulated and tumour suppressor lncRN...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Ageing research reviews 2016-03, Vol.26, p.1-21
Hauptverfasser:	Kour, Sukhleen, Rath, Pramod C
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - genetics Animals Cellular Senescence - physiology Chromatin Assembly and Disassembly - physiology Humans Internal Medicine Neurology RNA, Long Noncoding - physiology Telomere Homeostasis - physiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • Aging process involves decline in biological functions over the time. • Pervasive transcription of lncRNAs in mammals regulates various cellular processes. • LncRNAs could affect aging via chromatin modulation and telomere maintenance. • Various p53 regulated and tumour suppressor lncRNAs could affect onset of aging. • LncRNAs regulate various age-related diseases and disorders.
ISSN:	1568-1637 1872-9649
DOI:	10.1016/j.arr.2015.12.001