Histologic differences between primary high myopia and secondary high myopia due to congenital glaucoma
Purpose To search for histomorphometric differences between eyes with primary high myopia (PHM) or secondary high axial myopia (SHM) caused by congenital glaucoma, and non‐highly myopic eyes (NHM). Methods Histologic anterior–posterior sections were histomorphometrically examined. Results The invest...
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| Veröffentlicht in: | Acta ophthalmologica (Oxford, England) England), 2016-03, Vol.94 (2), p.147-153 |
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| creator | Jonas, Jost B. Holbach, Leonard Panda‐Jonas, Songhomitra |
| description | Purpose
To search for histomorphometric differences between eyes with primary high myopia (PHM) or secondary high axial myopia (SHM) caused by congenital glaucoma, and non‐highly myopic eyes (NHM).
Methods
Histologic anterior–posterior sections were histomorphometrically examined.
Results
The investigation included 58 human globes (mean age: 61.5 ± 18.5 years; axial length: 27.3 ± 4.0 mm; range: 21.0–39.0 mm). Bruch's membrane thickness was thinner in SHM than in PHM (posterior pole: p = 0.007; parapapillary region: p = 0.007); midpoint posterior pole/equator = 0.05) and thinner in SHM than in NHM (all p 0.50). Choroidal thickness did not differ (all p ≥ 0.40) at any measurement location between SHM and PHM, and was thinner (p |
| doi_str_mv | 10.1111/aos.12937 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1767627422</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1767627422</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4967-f0e6b2f09bc64c08b4686fdc8cf93fb15871b53b60e3613761f1db8e79a26793</originalsourceid><addsrcrecordid>eNp1kD1PwzAQhi0EoqUw8AeQRxja2vk4J2NVAUVC6kAHtsh2zqlREpc4UdV_TyClAxK33Envo0e6l5Bbzma8n7l0fsaDNBRnZMxFHE9DAcn56Y7fR-TK-w_GgANEl2QUAKQxZzAmxcr61pWusJrm1hhssNboqcJ2j1jTXWMr2Rzo1hZbWh3czkoq65x61K7O_yZ5h7R1tI8KrG0rS1qUstOuktfkwsjS481xT8jm6XGzXE1f188vy8XrVEcpiKlhCCowLFUaIs0SFUECJteJNmloFI8TwVUcKmAYAu_f5IbnKkGRygBEGk7I_aDdNe6zQ99mlfUay1LW6DqfcQECAhEFQY8-DKhunPcNmuz4a8ZZ9l1r1tea_dTas3dHbacqzE_kb489MB-AvS3x8L8pW6zfBuUXiBmDFA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1767627422</pqid></control><display><type>article</type><title>Histologic differences between primary high myopia and secondary high myopia due to congenital glaucoma</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Wiley Free Content</source><creator>Jonas, Jost B. ; Holbach, Leonard ; Panda‐Jonas, Songhomitra</creator><creatorcontrib>Jonas, Jost B. ; Holbach, Leonard ; Panda‐Jonas, Songhomitra</creatorcontrib><description>Purpose
To search for histomorphometric differences between eyes with primary high myopia (PHM) or secondary high axial myopia (SHM) caused by congenital glaucoma, and non‐highly myopic eyes (NHM).
Methods
Histologic anterior–posterior sections were histomorphometrically examined.
Results
The investigation included 58 human globes (mean age: 61.5 ± 18.5 years; axial length: 27.3 ± 4.0 mm; range: 21.0–39.0 mm). Bruch's membrane thickness was thinner in SHM than in PHM (posterior pole: p = 0.007; parapapillary region: p = 0.007); midpoint posterior pole/equator = 0.05) and thinner in SHM than in NHM (all p < 0.04), while PHM and NHM did not differ (all p > 0.50). Choroidal thickness did not differ (all p ≥ 0.40) at any measurement location between SHM and PHM, and was thinner (p < 0.05) in both myopic groups than in NHM. Posterior sclera was thinner (p < 0.001) in both myopic groups than in NHM, with no significant difference between both myopic groups. Pars plana scleral thickness was thinner (p = 0.02) in SHM than in PHM after adjusting for axial length. Scleral volume (p = 0.41) and choroidal volume (p = 0.74) did not differ between any of the groups.
Conclusions
Thinning of Bruch's membrane overall is typical for SHM while eyes with PHM have a normal Bruch's membrane thickness. It may point to Bruch's membrane as an active part in the process of emmetropization/myopization. SHM in contrast to PHM showed scleral thinning in the pars plana region suggesting that the process of emmetropization/myopization takes place posterior to the pars plana. Both SHM and PHM unspecifically showed an axial length associated with thinning of choroid and posterior sclera, while both myopic groups did not differ with NHM in choroidal and scleral volume.</description><identifier>ISSN: 1755-375X</identifier><identifier>EISSN: 1755-3768</identifier><identifier>DOI: 10.1111/aos.12937</identifier><identifier>PMID: 26695106</identifier><language>eng</language><publisher>England</publisher><subject>Adult ; Aged ; Axial Length, Eye - pathology ; Bruch Membrane - pathology ; Choroid - pathology ; choroidal thickness ; congenital glaucoma ; emmetropization ; high myopia ; Humans ; Hydrophthalmos - complications ; Intraocular Pressure ; Middle Aged ; myopia ; Myopia, Degenerative - etiology ; Myopia, Degenerative - pathology ; myopization ; ocular elongation ; Optic Disk - pathology ; Sclera - pathology ; scleral thickness</subject><ispartof>Acta ophthalmologica (Oxford, England), 2016-03, Vol.94 (2), p.147-153</ispartof><rights>2015 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd</rights><rights>2015 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4967-f0e6b2f09bc64c08b4686fdc8cf93fb15871b53b60e3613761f1db8e79a26793</citedby><cites>FETCH-LOGICAL-c4967-f0e6b2f09bc64c08b4686fdc8cf93fb15871b53b60e3613761f1db8e79a26793</cites><orcidid>0000-0003-2972-5227</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Faos.12937$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Faos.12937$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,1428,27905,27906,45555,45556,46390,46814</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26695106$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jonas, Jost B.</creatorcontrib><creatorcontrib>Holbach, Leonard</creatorcontrib><creatorcontrib>Panda‐Jonas, Songhomitra</creatorcontrib><title>Histologic differences between primary high myopia and secondary high myopia due to congenital glaucoma</title><title>Acta ophthalmologica (Oxford, England)</title><addtitle>Acta Ophthalmol</addtitle><description>Purpose
To search for histomorphometric differences between eyes with primary high myopia (PHM) or secondary high axial myopia (SHM) caused by congenital glaucoma, and non‐highly myopic eyes (NHM).
Methods
Histologic anterior–posterior sections were histomorphometrically examined.
Results
The investigation included 58 human globes (mean age: 61.5 ± 18.5 years; axial length: 27.3 ± 4.0 mm; range: 21.0–39.0 mm). Bruch's membrane thickness was thinner in SHM than in PHM (posterior pole: p = 0.007; parapapillary region: p = 0.007); midpoint posterior pole/equator = 0.05) and thinner in SHM than in NHM (all p < 0.04), while PHM and NHM did not differ (all p > 0.50). Choroidal thickness did not differ (all p ≥ 0.40) at any measurement location between SHM and PHM, and was thinner (p < 0.05) in both myopic groups than in NHM. Posterior sclera was thinner (p < 0.001) in both myopic groups than in NHM, with no significant difference between both myopic groups. Pars plana scleral thickness was thinner (p = 0.02) in SHM than in PHM after adjusting for axial length. Scleral volume (p = 0.41) and choroidal volume (p = 0.74) did not differ between any of the groups.
Conclusions
Thinning of Bruch's membrane overall is typical for SHM while eyes with PHM have a normal Bruch's membrane thickness. It may point to Bruch's membrane as an active part in the process of emmetropization/myopization. SHM in contrast to PHM showed scleral thinning in the pars plana region suggesting that the process of emmetropization/myopization takes place posterior to the pars plana. Both SHM and PHM unspecifically showed an axial length associated with thinning of choroid and posterior sclera, while both myopic groups did not differ with NHM in choroidal and scleral volume.</description><subject>Adult</subject><subject>Aged</subject><subject>Axial Length, Eye - pathology</subject><subject>Bruch Membrane - pathology</subject><subject>Choroid - pathology</subject><subject>choroidal thickness</subject><subject>congenital glaucoma</subject><subject>emmetropization</subject><subject>high myopia</subject><subject>Humans</subject><subject>Hydrophthalmos - complications</subject><subject>Intraocular Pressure</subject><subject>Middle Aged</subject><subject>myopia</subject><subject>Myopia, Degenerative - etiology</subject><subject>Myopia, Degenerative - pathology</subject><subject>myopization</subject><subject>ocular elongation</subject><subject>Optic Disk - pathology</subject><subject>Sclera - pathology</subject><subject>scleral thickness</subject><issn>1755-375X</issn><issn>1755-3768</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kD1PwzAQhi0EoqUw8AeQRxja2vk4J2NVAUVC6kAHtsh2zqlREpc4UdV_TyClAxK33Envo0e6l5Bbzma8n7l0fsaDNBRnZMxFHE9DAcn56Y7fR-TK-w_GgANEl2QUAKQxZzAmxcr61pWusJrm1hhssNboqcJ2j1jTXWMr2Rzo1hZbWh3czkoq65x61K7O_yZ5h7R1tI8KrG0rS1qUstOuktfkwsjS481xT8jm6XGzXE1f188vy8XrVEcpiKlhCCowLFUaIs0SFUECJteJNmloFI8TwVUcKmAYAu_f5IbnKkGRygBEGk7I_aDdNe6zQ99mlfUay1LW6DqfcQECAhEFQY8-DKhunPcNmuz4a8ZZ9l1r1tea_dTas3dHbacqzE_kb489MB-AvS3x8L8pW6zfBuUXiBmDFA</recordid><startdate>201603</startdate><enddate>201603</enddate><creator>Jonas, Jost B.</creator><creator>Holbach, Leonard</creator><creator>Panda‐Jonas, Songhomitra</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2972-5227</orcidid></search><sort><creationdate>201603</creationdate><title>Histologic differences between primary high myopia and secondary high myopia due to congenital glaucoma</title><author>Jonas, Jost B. ; Holbach, Leonard ; Panda‐Jonas, Songhomitra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4967-f0e6b2f09bc64c08b4686fdc8cf93fb15871b53b60e3613761f1db8e79a26793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Axial Length, Eye - pathology</topic><topic>Bruch Membrane - pathology</topic><topic>Choroid - pathology</topic><topic>choroidal thickness</topic><topic>congenital glaucoma</topic><topic>emmetropization</topic><topic>high myopia</topic><topic>Humans</topic><topic>Hydrophthalmos - complications</topic><topic>Intraocular Pressure</topic><topic>Middle Aged</topic><topic>myopia</topic><topic>Myopia, Degenerative - etiology</topic><topic>Myopia, Degenerative - pathology</topic><topic>myopization</topic><topic>ocular elongation</topic><topic>Optic Disk - pathology</topic><topic>Sclera - pathology</topic><topic>scleral thickness</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jonas, Jost B.</creatorcontrib><creatorcontrib>Holbach, Leonard</creatorcontrib><creatorcontrib>Panda‐Jonas, Songhomitra</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta ophthalmologica (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jonas, Jost B.</au><au>Holbach, Leonard</au><au>Panda‐Jonas, Songhomitra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histologic differences between primary high myopia and secondary high myopia due to congenital glaucoma</atitle><jtitle>Acta ophthalmologica (Oxford, England)</jtitle><addtitle>Acta Ophthalmol</addtitle><date>2016-03</date><risdate>2016</risdate><volume>94</volume><issue>2</issue><spage>147</spage><epage>153</epage><pages>147-153</pages><issn>1755-375X</issn><eissn>1755-3768</eissn><abstract>Purpose
To search for histomorphometric differences between eyes with primary high myopia (PHM) or secondary high axial myopia (SHM) caused by congenital glaucoma, and non‐highly myopic eyes (NHM).
Methods
Histologic anterior–posterior sections were histomorphometrically examined.
Results
The investigation included 58 human globes (mean age: 61.5 ± 18.5 years; axial length: 27.3 ± 4.0 mm; range: 21.0–39.0 mm). Bruch's membrane thickness was thinner in SHM than in PHM (posterior pole: p = 0.007; parapapillary region: p = 0.007); midpoint posterior pole/equator = 0.05) and thinner in SHM than in NHM (all p < 0.04), while PHM and NHM did not differ (all p > 0.50). Choroidal thickness did not differ (all p ≥ 0.40) at any measurement location between SHM and PHM, and was thinner (p < 0.05) in both myopic groups than in NHM. Posterior sclera was thinner (p < 0.001) in both myopic groups than in NHM, with no significant difference between both myopic groups. Pars plana scleral thickness was thinner (p = 0.02) in SHM than in PHM after adjusting for axial length. Scleral volume (p = 0.41) and choroidal volume (p = 0.74) did not differ between any of the groups.
Conclusions
Thinning of Bruch's membrane overall is typical for SHM while eyes with PHM have a normal Bruch's membrane thickness. It may point to Bruch's membrane as an active part in the process of emmetropization/myopization. SHM in contrast to PHM showed scleral thinning in the pars plana region suggesting that the process of emmetropization/myopization takes place posterior to the pars plana. Both SHM and PHM unspecifically showed an axial length associated with thinning of choroid and posterior sclera, while both myopic groups did not differ with NHM in choroidal and scleral volume.</abstract><cop>England</cop><pmid>26695106</pmid><doi>10.1111/aos.12937</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-2972-5227</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Axial Length, Eye - pathology Bruch Membrane - pathology Choroid - pathology choroidal thickness congenital glaucoma emmetropization high myopia Humans Hydrophthalmos - complications Intraocular Pressure Middle Aged myopia Myopia, Degenerative - etiology Myopia, Degenerative - pathology myopization ocular elongation Optic Disk - pathology Sclera - pathology scleral thickness |
| title | Histologic differences between primary high myopia and secondary high myopia due to congenital glaucoma |
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