Patient-derived xenograft models of squamous cell carcinoma of the uterine cervix

Highlights • The PDX models mirror the biology and aggressiveness of the donor patients' tumors. • Metastasis of the PDXs is associated with the presence of intratumoral lymphatics. • Metastasis of the PDXs is related to high expression of angiogenesis-related genes. • Metastasis of the PDXs co...

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Veröffentlicht in:	Cancer letters 2016-04, Vol.373 (2), p.147-155
Hauptverfasser:	Rofstad, Einar K, Simonsen, Trude G, Huang, Ruixia, Andersen, Lise Mari K, Galappathi, Kanthi, Ellingsen, Christine, Wegner, Catherine S, Hauge, Anette, Gaustad, Jon-Vidar
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Cancer stem cells Carcinoma, Squamous Cell - pathology Cervical cancer Cervical carcinoma Chemokines Conflicts of interest Female Fibroblasts Growth factors Hematology, Oncology and Palliative Medicine Heterografts Humans Kinases Ligands Lymphangiogenesis Lymphatic Metastasis Lymphatic system Metastasis Mice Mice, Inbred BALB C Middle Aged Neoplasm Transplantation PDX models Stem cells Transcription factors Tumors Uterine Cervical Neoplasms - pathology
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Beschreibung
Zusammenfassung:	Highlights • The PDX models mirror the biology and aggressiveness of the donor patients' tumors. • Metastasis of the PDXs is associated with the presence of intratumoral lymphatics. • Metastasis of the PDXs is related to high expression of angiogenesis-related genes. • Metastasis of the PDXs correlates with high expression of stem cell-related genes.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2016.01.047