Inhibition of NF-κB translocation by curcumin analogs induces G0/G1 arrest and downregulates thymidylate synthase in colorectal cancer

Highlights • UBS109 and EF31 are more potent inhibitors of cell cycle progression than curcumin. • UBS109 and EF31 inhibit NF-κB and TS leading to decreased DNA synthesis. • UBS109 and EF31 and curcumin induce expression of silenced p16 and p21. • UBS109 and EF31 are promising analogues for future t...

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Veröffentlicht in:	Cancer letters 2016-04, Vol.373 (2), p.227-233
Hauptverfasser:	Rajitha, Balney, Belalcazar, Astrid, Nagaraju, Ganji Purnachandra, Shaib, Walid L, Snyder, James P, Shoji, Mamoru, Pattnaik, Subasini, Alam, Afroz, El-Rayes, Bassel F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Cycle Checkpoints - drug effects Cell Line, Tumor colorectal cancer Colorectal Neoplasms - drug therapy Colorectal Neoplasms - pathology Curcumin Curcumin - analogs & derivatives Curcumin - pharmacology Down-Regulation EF31 Female Hematology, Oncology and Palliative Medicine Humans Mice NF-kappa B - antagonists & inhibitors NF-kappa B - physiology nuclear factor kappa B Piperidones - pharmacology Protein Transport - drug effects Pyridines - pharmacology Thymidylate Synthase - antagonists & inhibitors UBS109
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Zusammenfassung:	Highlights • UBS109 and EF31 are more potent inhibitors of cell cycle progression than curcumin. • UBS109 and EF31 inhibit NF-κB and TS leading to decreased DNA synthesis. • UBS109 and EF31 and curcumin induce expression of silenced p16 and p21. • UBS109 and EF31 are promising analogues for future therapeutic development in CRC.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2016.01.052