Harnessing QbD, Programming Languages, and Automation for Reproducible Biology
Building robust manufacturing processes from biological components is a task that is highly complex and requires sophisticated tools to describe processes, inputs, and measurements and administrate management of knowledge, data, and materials. We argue that for bioengineering to fully access biologi...
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| Veröffentlicht in: | Trends in biotechnology (Regular ed.) 2016-03, Vol.34 (3), p.214-227 |
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| container_title | Trends in biotechnology (Regular ed.) |
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| creator | Sadowski, Michael I Grant, Chris Fell, Tim S |
| description | Building robust manufacturing processes from biological components is a task that is highly complex and requires sophisticated tools to describe processes, inputs, and measurements and administrate management of knowledge, data, and materials. We argue that for bioengineering to fully access biological potential, it will require application of statistically designed experiments to derive detailed empirical models of underlying systems. This requires execution of large-scale structured experimentation for which laboratory automation is necessary. This requires development of expressive, high-level languages that allow reusability of protocols, characterization of their reliability, and a change in focus from implementation details to functional properties. We review recent developments in these areas and identify what we believe is an exciting trend that promises to revolutionize biotechnology. |
| doi_str_mv | 10.1016/j.tibtech.2015.11.006 |
| format | Article |
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| ispartof | Trends in biotechnology (Regular ed.), 2016-03, Vol.34 (3), p.214-227 |
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| subjects | Automation Bioengineering - methods Bioengineering - standards Biology Biotechnology Biotechnology - methods Biotechnology - standards complexity Design of experiments Internal Medicine laboratory automation Manufacturing industry Medical research Productivity Programming Languages quality by design reproducibility Reproducibility of Results Studies |
| title | Harnessing QbD, Programming Languages, and Automation for Reproducible Biology |
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