K-RAS mutations indicating primary resistance to crizotinib in ALK -rearranged adenocarcinomas of the lung: Report of two cases and review of the literature

Highlights • K-RAS and ALK alterations in NSCLC may co-exist. • K-RAS mutations confer crizotinib resistance to ALK-rearranged NSCLC. • K-RAS appears a strong negative predictive marker in oncogenic-driven NSCLC.

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Veröffentlicht in:	Lung cancer (Amsterdam, Netherlands) Netherlands), 2016-03, Vol.93, p.55-58
Hauptverfasser:	Mengoli, Maria Cecilia, Barbieri, Fausto, Bertolini, Federica, Tiseo, Marcello, Rossi, Giulio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenocarcinoma - diagnosis Adenocarcinoma - drug therapy Adenocarcinoma - genetics Adenocarcinoma of Lung ALK Anaplastic Lymphoma Kinase Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Crizotinib DNA Mutational Analysis Drug Resistance, Neoplasm - genetics Fatal Outcome Female Hematology, Oncology and Palliative Medicine Humans Immunohistochemistry In Situ Hybridization, Fluorescence K-RAS Lung Lung Neoplasms - diagnosis Lung Neoplasms - drug therapy Lung Neoplasms - genetics Male Middle Aged Mutation Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Proto-Oncogene Proteins p21(ras) - genetics Pulmonary/Respiratory Pyrazoles - pharmacology Pyrazoles - therapeutic use Pyridines - pharmacology Pyridines - therapeutic use Receptor Protein-Tyrosine Kinases - antagonists & inhibitors Receptor Protein-Tyrosine Kinases - genetics Resistance Tomography, X-Ray Computed Translocation, Genetic Treatment Outcome
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Beschreibung
Zusammenfassung:	Highlights • K-RAS and ALK alterations in NSCLC may co-exist. • K-RAS mutations confer crizotinib resistance to ALK-rearranged NSCLC. • K-RAS appears a strong negative predictive marker in oncogenic-driven NSCLC.
ISSN:	0169-5002 1872-8332
DOI:	10.1016/j.lungcan.2016.01.002