A New Cytotoxic Polyhydroxysterol from Soft Coral Sarcophyton trocheliophorum

A new cytotoxic polyhydroxysterol, 23, 24, -dimethylcholest-16(17)-E-en-3β, 5α, 6β, 20(S)-tetraol (2), together with nine known compounds was isolated from the soft coral Sarcophyton trocheliophorum. Their structures were determined by spectroscopic methods. Compound 2 showed potent growth inhibitor...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2000/07/01, Vol.48(7), pp.1087-1089
Hauptverfasser:	DONG, Hui, GOU, Yu-Lin, KINI, R.Manjunatha, XU, Hong-Xi, CHEN, Shao-Xing, TEO, Serena Lay Ming, BUT, Paul Pui-Hay
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Biological and medical sciences Cell Division - drug effects Cholestenes - chemistry Cholestenes - isolation & purification Cholestenes - pharmacology Cnidaria - chemistry Drug Screening Assays, Antitumor General pharmacology HL-60 Cells Humans Marine Medical sciences natural products Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments polyhydroxysterol polyhydroxysterols Sarcophyton trocheliophorum Soft coral Tumor Cells, Cultured
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Zusammenfassung:	A new cytotoxic polyhydroxysterol, 23, 24, -dimethylcholest-16(17)-E-en-3β, 5α, 6β, 20(S)-tetraol (2), together with nine known compounds was isolated from the soft coral Sarcophyton trocheliophorum. Their structures were determined by spectroscopic methods. Compound 2 showed potent growth inhibitory activity against human HL60 leukemia, M14 skin melanoma, and MCF7 breast carcinoma cells with EC50 values of 2.8, 4.3, and 4.9 μg/ml, respectively, and exhibited minimal toxicity to normal human peripheral blood lymphocytes.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.48.1087