Drug-drug co-crystallization presents a new opportunity for the development of stable vitamins

Drug-drug co-crystallization could realize combination drugs at a molecular level. Two polymorphic co-crystals between VD 2 and VD 3 were successfully designed and synthesized. These enantiotropic polymorphs exhibit significantly different physicochemical stabilities. Two packing polymorphs of drug-...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2016-02, Vol.52 (17), p.3572-3575
Hauptverfasser:	Wang, Jian-Rong, Yu, Qihui, Dai, Wenjuan, Mei, Xuefeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Cholecalciferol - chemistry Chromatography, High Pressure Liquid Crystallization Drugs Ergocalciferols - chemistry Hydrogen Bonding Magnetic Resonance Spectroscopy Pharmaceutical Preparations - chemistry Powder Diffraction Stability Thermogravimetry Vitamins
Online-Zugang:	Volltext
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