Drug-drug co-crystallization presents a new opportunity for the development of stable vitamins

Drug-drug co-crystallization could realize combination drugs at a molecular level. Two polymorphic co-crystals between VD 2 and VD 3 were successfully designed and synthesized. These enantiotropic polymorphs exhibit significantly different physicochemical stabilities. Two packing polymorphs of drug-drug co-crystals between VD 2 and VD 3 exhibit dramatically different properties. Form A presents superior physicochemical properties compared with VD 2 or VD 3 themselves.