High Ki67 expression is an independent good prognostic marker in colorectal cancer

High Ki67 expression is an independent good prognostic marker in colorectal cancer

AimsTo correlate Ki67 expression with outcome in colorectal cancer (CRC).MethodsKi67 labelling index (Ki67LI) was analysed by immunohistochemistry on a tissue microarray containing 1800 CRCs. The results were compared with clinicopathological and molecular parameters.ResultsKi67LI was considered low...

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Veröffentlicht in:Journal of clinical pathology 2016-03, Vol.69 (3), p.209-214
Hauptverfasser: Melling, Nathaniel, Kowitz, Charlotte Marie, Simon, Ronald, Bokemeyer, Carsten, Terracciano, Luigi, Sauter, Guido, Izbicki, Jakob Robert, Marx, Andreas Holger
Format: Artikel
Sprache:eng
Schlagworte:
Age
Aged
beta Catenin - analysis
Breast cancer
Cancer therapies
Cell cycle
Cell growth
Cell Proliferation
Chemotherapy
Colorectal cancer
Colorectal Neoplasms - chemistry
Colorectal Neoplasms - mortality
Colorectal Neoplasms - pathology
Colorectal Neoplasms - therapy
Female
Humans
Immunohistochemistry
Kaplan-Meier Estimate
Ki-67 Antigen - analysis
Localization
Lymphatic Metastasis
Male
Medical prognosis
Metastasis
Middle Aged
Multivariate Analysis
Neoplasm Staging
Pathology
Predictive Value of Tests
Proportional Hazards Models
Studies
Surgery
Time Factors
Tissue Array Analysis
Treatment Outcome
Tumor Suppressor Protein p53 - analysis
Tumors
Up-Regulation
Variance analysis
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Zusammenfassung:AimsTo correlate Ki67 expression with outcome in colorectal cancer (CRC).MethodsKi67 labelling index (Ki67LI) was analysed by immunohistochemistry on a tissue microarray containing 1800 CRCs. The results were compared with clinicopathological and molecular parameters.ResultsKi67LI was considered low in 26.3%, moderate in 56.7% and high in 17.0% of 1653 interpretable CRCs. High Ki67 expression was associated with low tumour stage (p
ISSN:0021-9746
1472-4146
DOI:10.1136/jclinpath-2015-202985