Ruthenium-Catalyzed Intermolecular Direct Silylation of Unreactive C(sp3)–H Bonds

Ruthenium-Catalyzed Intermolecular Direct Silylation of Unreactive C(sp3)–H Bonds

A Ru-catalyzed intermolecular silylation of unreactive, aliphatic C­(sp3)–H bonds has been described for the first time. This protocol features low catalyst loading, a relatively broad substrate spectrum, good functional group tolerance, and no sensitivity to air, which provides a convenient and pra...

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Veröffentlicht in:Organic letters 2016-02, Vol.18 (4), p.666-668
Hauptverfasser: Li, Wei, Huang, Xiaolei, You, Jingsong
Format: Artikel
Sprache:eng
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Zusammenfassung:A Ru-catalyzed intermolecular silylation of unreactive, aliphatic C­(sp3)–H bonds has been described for the first time. This protocol features low catalyst loading, a relatively broad substrate spectrum, good functional group tolerance, and no sensitivity to air, which provides a convenient and practical pathway for the construction of C–Si bonds.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.5b03593