Immunopathological effect of the mycotoxins cyclopiazonic acid and T-2 toxin on broiler chicken

Forty, newly hatched, unsexed broiler chicks were fed diets containing 10 ppm cyclopiazonic acid (CPA) and 1 ppm T-2 toxin (T2) either individually or in combination for 28 days to study the immunopathological effects. Lymphoid organs revealed lymphocytolysis and lymphoid depletion in all toxin fed...

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Veröffentlicht in:	Mycopathologia (1975) 2005-02, Vol.159 (2), p.273-279
Hauptverfasser:	Kamalavenkatesh, P, Vairamuthu, S, Balachandran, C, Manohar, B.M, Dhinakar Raj, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Viral - blood antibody formation broiler chickens CD4-positive T-lymphocytes CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - immunology CD8-positive T-lymphocytes CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - immunology Cell Proliferation - drug effects Chickens - immunology cyclopiazonic acid Enzyme Inhibitors - toxicity Flow Cytometry - veterinary hemagglutination inhibition test Hemagglutination Inhibition Tests - veterinary immunosuppression (physiological) immunotoxicity Indoles - toxicity Lymphocyte Subsets - immunology mycotoxins Newcastle disease virus Newcastle disease virus - immunology Poultry Diseases - immunology Poultry Diseases - pathology spleen Spleen - drug effects Spleen - immunology splenocytes T-2 toxin T-2 Toxin - toxicity thymus gland Thymus Gland - drug effects Thymus Gland - immunology
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Beschreibung
Zusammenfassung:	Forty, newly hatched, unsexed broiler chicks were fed diets containing 10 ppm cyclopiazonic acid (CPA) and 1 ppm T-2 toxin (T2) either individually or in combination for 28 days to study the immunopathological effects. Lymphoid organs revealed lymphocytolysis and lymphoid depletion in all toxin fed birds. Thymic and splenic CD+4 and CD+8 lymphocytes decreased significantly (p
ISSN:	0301-486X 1573-0832
DOI:	10.1007/s11046-004-7321-0