A New Triterpenoid from the Aerial Parts of Agrimonia pilosa

A New Triterpenoid from the Aerial Parts of Agrimonia pilosa

(1S,3R,17R,18R,19R,20R,22R)-1,3,19,22-tetrahydroxy-28-norurs-12-en-2-one (1), along with 5 known triterpenoids (2–6), were isolated from the aerial parts of Agrimonia pilosa Ledeb. Their structures were established based on extensive spectroscopic and MS analysis. The absolute configuration of compo...

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Veröffentlicht in:Natural product communications 2015-12, Vol.10 (12), p.2041-2044
Hauptverfasser: Ma, Jiang-Hao, Jiang, Qing-Hua, Chen, Ying, Nie, Xiu-Fang, Yao, Tie, Ding, Li-Qin, Zhao, Feng, Chen, Li-Xia, Feng, Qiu
Format: Artikel
Sprache:eng
Schlagworte:
Agrimonia - chemistry
Animals
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - pharmacology
Cell Line
Macrophages - drug effects
Mice
Molecular Structure
Plant Components, Aerial - chemistry
Triterpenes - chemistry
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Zusammenfassung:(1S,3R,17R,18R,19R,20R,22R)-1,3,19,22-tetrahydroxy-28-norurs-12-en-2-one (1), along with 5 known triterpenoids (2–6), were isolated from the aerial parts of Agrimonia pilosa Ledeb. Their structures were established based on extensive spectroscopic and MS analysis. The absolute configuration of compound 1 was deduced by circular dichroism (CD). Compound 1 was the first example of a 28-norursene backbone isolated from the genus Agrimonia. Compounds 2–6 were tested for anti-inflammatory activities against RAW 264.7 macrophages. A plausible biosynthetic pathway for compound 1 in A. pilosa was also proposed.
ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X1501001207