Cholinergic excitation from the pedunculopontine tegmental nucleus to the dentate nucleus in the rat

Highlights • Stimulation of the pedunculopontine tegmental nucleus excited cerebellar nuclei. • The excitation was mediated by neuronal cell bodies in the stimulated site. • Iontophoretic application of acetylcholine antagonists blocked the evoked response. • These data may help to explain deep-brai...

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Veröffentlicht in:	Neuroscience 2016-03, Vol.317, p.12-22
Hauptverfasser:	Vitale, F, Mattei, C, Capozzo, A, Pietrantoni, I, Mazzone, P, Scarnati, E
Format:	Artikel
Sprache:	eng
Schlagworte:	acetylcholine Acetylcholine - metabolism Action Potentials - drug effects Animals Biophysics Cerebellar Nuclei - physiology cerebellum Cholinergic Agents - pharmacology Cholinergic Fibers Electric Stimulation electrophysiology Iontophoresis Male NADPH Dehydrogenase - metabolism Neural Pathways - physiology neurodegenerative disorders Neurology Neurons - drug effects Neurons - physiology Patch-Clamp Techniques pedunculopontine tegmental nucleus Pedunculopontine Tegmental Nucleus - cytology Pedunculopontine Tegmental Nucleus - physiology Rats Rats, Wistar Reaction Time
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Zusammenfassung:	Highlights • Stimulation of the pedunculopontine tegmental nucleus excited cerebellar nuclei. • The excitation was mediated by neuronal cell bodies in the stimulated site. • Iontophoretic application of acetylcholine antagonists blocked the evoked response. • These data may help to explain deep-brain stimulation effects in motor disorders.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.12.055