Infusion of basic fibroblast growth factor ameliorates acute graft versus host disease in mice after haploidentical hematopoietic stem cell transplantation

Highlights • bFGF infusion ameliorated clinical manifestations of aGVHD. • bFGF infusion prolonged the survival time of mice after transplantation. • bFGF infusion reduced the severity of aGVHD.

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Bibliographische Detailangaben
Veröffentlicht in:	Immunology letters 2016-02, Vol.170, p.1-6
Hauptverfasser:	Fan, Fangyi, Fu, Li, He, Guangcui, Deng, Rui, Qiu, Ling, Liu, Yilan, Miao, Xiaojuan, Shuai, Yanrong, Su, Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute graft versus host disease Allergy and Immunology Animals Basic fibroblast growth factor Bone Marrow Cells - drug effects Bone Marrow Cells - metabolism Cell Differentiation Disease Models, Animal Female Fibroblast Growth Factor 2 - administration & dosage Graft vs Host Disease - diagnosis Graft vs Host Disease - drug therapy Graft vs Host Disease - etiology Graft vs Host Disease - mortality Hematopoietic stem cell transplantation Hematopoietic Stem Cell Transplantation - adverse effects Leukocyte Count Liver - drug effects Liver - pathology Male Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - drug effects Mesenchymal Stromal Cells - metabolism Mice Phenotype Transplantation, Homologous
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Beschreibung
Zusammenfassung:	Highlights • bFGF infusion ameliorated clinical manifestations of aGVHD. • bFGF infusion prolonged the survival time of mice after transplantation. • bFGF infusion reduced the severity of aGVHD.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2015.11.015