Treatments for erectile dysfunction in spinal cord patients: alternatives to phosphodiesterase type 5 inhibitors? A review study

Study design: Review study. Objectives: Alternative treatments to oral phosphodiesterase type 5 inhibitors (PDE5Is) in individuals with spinal cord lesions (SCLs) and erectile dysfunction (ED). Setting: Italy. Methods: Research clinical trials (1999–2014). Results: Twelve studies were selected. One...

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Veröffentlicht in:	Spinal cord 2015-12, Vol.53 (12), p.849-854
Hauptverfasser:	Lombardi, G, Musco, S, Wyndaele, J J, Del Popolo, G
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Aminopyridine - therapeutic use 692/699/2768/1575 692/699/2768/515 Anatomy Biomedical and Life Sciences Biomedicine Clinical Trials as Topic - statistics & numerical data Dose-Response Relationship, Drug Erectile Dysfunction - drug therapy Erectile Dysfunction - etiology Human Physiology Humans Longitudinal Studies Male MEDLINE - statistics & numerical data Neurochemistry Neuropsychology Neurosciences Phosphodiesterase 5 Inhibitors - therapeutic use review Spinal Cord Injuries - complications Spinal Cord Injuries - drug therapy Spinal Cord Injuries - surgery
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Zusammenfassung:	Study design: Review study. Objectives: Alternative treatments to oral phosphodiesterase type 5 inhibitors (PDE5Is) in individuals with spinal cord lesions (SCLs) and erectile dysfunction (ED). Setting: Italy. Methods: Research clinical trials (1999–2014). Results: Twelve studies were selected. One article documented that 76% of subjects reached satisfactory sexual intercourse (SI) using intracavernosal injection of vasoactive medications (papaverine and prostaglandin E1). One study regarding perineal training showed a significant increase ( P
ISSN:	1362-4393 1476-5624
DOI:	10.1038/sc.2015.116