Potential of novel phytoecdysteroids isolated from Vitex doniana in the treatment depression: Involvement of monoaminergic systems

Vitex doniana Sweet (Verbanaceae) is used in traditional African medicine for the treatment of neurological disorders including depression. In our previous studies, three new phytoecdysteroids were isolated from methanol stem bark extract of V. doniana (VD) (11β-hydroxy-20-deoxyshidasterone, 21-hydr...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 2014-12, Vol.127, p.90-100
Hauptverfasser:	Ishola, Ismail O., Ochieng, Charles O., Olayemi, Sunday O., Jimoh, Memunat O., Lawal, Saheed M.
Format:	Artikel
Sprache:	eng
Schlagworte:	11β-Hydroxy-20-deoxyshidasterone 2,3-Acetonide-24-hydroxyecdysone 21-Hydroxyshidasterone 5-HT2A/2C Animals Depression Depression - drug therapy Depression - metabolism Depression - psychology Forced swim test Male Mice Phytosterols - isolation & purification Phytosterols - metabolism Phytosterols - therapeutic use Plant Bark Plant Extracts - isolation & purification Plant Extracts - metabolism Plant Extracts - therapeutic use Receptors, Adrenergic - metabolism Receptors, Biogenic Amine - metabolism Receptors, Dopamine - metabolism Receptors, Serotonin - metabolism Treatment Outcome Vitex
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Zusammenfassung:	Vitex doniana Sweet (Verbanaceae) is used in traditional African medicine for the treatment of neurological disorders including depression. In our previous studies, three new phytoecdysteroids were isolated from methanol stem bark extract of V. doniana (VD) (11β-hydroxy-20-deoxyshidasterone, 21-hydroxyshidasterone, and 2,3-acetonide-24-hydroxyecdysone) along with known ecdysteroids. This study was designed to investigate antidepressant-like effect of VD and the isolated phytoecdysteroids in behavioral models of despair, forced-swim test (FST) and tail-suspension test (TST) in mice. VD (100 and 200mg/kg, p.o.) treatment reduced (P
ISSN:	0091-3057 1873-5177
DOI:	10.1016/j.pbb.2014.11.005