Association between delta-aminolevulinic acid dehydratase polymorphism and placental lead levels

Association between delta-aminolevulinic acid dehydratase polymorphism and placental lead levels

Highlights • Maternal ALAD G177C polymorphism was associated with placental lead levels. • Mothers with ALAD2 allele had higher placental lead levels than those with ALAD1 allele. • Mothers with ALAD1 allele may be more advantageous in terms of having lower placental lead levels.

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Veröffentlicht in:Environmental toxicology and pharmacology 2016-01, Vol.41, p.147-151
Hauptverfasser: Kayaaltı, Zeliha, Sert, Selda, Kaya-Akyüzlü, Dilek, Söylemez, Esma, Söylemezoğlu, Tülin
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Delta-aminolevulinic acid dehydratase (ALAD)
Emergency
Female
G177C single-nucleotide polymorphism
Genetic Association Studies
Genotype
Humans
Lead
Lead - analysis
Maternal blood
Maternal Exposure
Placenta
Placenta - chemistry
Polymorphism, Single Nucleotide
Porphobilinogen Synthase - genetics
Pregnancy
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Zusammenfassung:Highlights • Maternal ALAD G177C polymorphism was associated with placental lead levels. • Mothers with ALAD2 allele had higher placental lead levels than those with ALAD1 allele. • Mothers with ALAD1 allele may be more advantageous in terms of having lower placental lead levels.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2015.11.017