Genome- and exome-wide association study of serum lipoprotein (a) in the Jackson Heart Study

Lipoprotein (a) (Lp(a)) is an independent risk factor for cardiovascular disease. Lp(a) levels in African Americans (AAs) are much higher compared with that in European Americans. We conducted a genome- and an exome-wide association study of Lp(a) among 2895 AAs participating in the Jackson Heart St...

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Veröffentlicht in:	Journal of human genetics 2015-12, Vol.60 (12), p.755-761
Hauptverfasser:	Li, Jin, Lange, Leslie A, Sabourin, Jeremy, Duan, Qing, Valdar, William, Willis, Monte S, Li, Yun, Wilson, James G, Lange, Ethan M
Format:	Artikel
Sprache:	eng
Schlagworte:	African Americans Age Apolipoprotein E Apolipoproteins Apolipoproteins E - genetics Body mass index Cardiovascular diseases Cardiovascular Diseases - genetics Chromosome 6 Chromosomes, Human, Pair 6 - genetics European Continental Ancestry Group Female Genetics Genome-Wide Association Study Genomes Genotype & phenotype Heart Humans Lipoprotein(a) - genetics Lipoproteins Male Mississippi Polymorphism, Single Nucleotide Risk factors Single-nucleotide polymorphism Studies
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Zusammenfassung:	Lipoprotein (a) (Lp(a)) is an independent risk factor for cardiovascular disease. Lp(a) levels in African Americans (AAs) are much higher compared with that in European Americans. We conducted a genome- and an exome-wide association study of Lp(a) among 2895 AAs participating in the Jackson Heart Study. We observed that local ancestry at 6q25.3 was an important risk factor for Lp(a) in AAs, and that multiple single-nucleotide polymorphisms (SNPs) at the well-established LPA locus were significantly associated with Lp(a) (P
ISSN:	1434-5161 1435-232X
DOI:	10.1038/jhg.2015.107