Impact of Growth Hormone on Adult Bone Quality in Turner Syndrome: A HR-pQCT Study

Women with Turner syndrome (TS) are known to be at risk of osteoporosis. While childhood growth hormone (GH) treatment is common in TS, the impact of this therapy on bone health has been poorly understood. The objective of this study was to determine the influence of childhood GH treatment on adult...

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Veröffentlicht in:Calcified tissue international 2016-01, Vol.98 (1), p.49-59
Hauptverfasser: Nour, Munier A., Burt, Lauren A., Perry, Rebecca J., Stephure, David K., Hanley, David A., Boyd, Steven K.
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Sprache:eng
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Zusammenfassung:Women with Turner syndrome (TS) are known to be at risk of osteoporosis. While childhood growth hormone (GH) treatment is common in TS, the impact of this therapy on bone health has been poorly understood. The objective of this study was to determine the influence of childhood GH treatment on adult bone quality in women with TS. 28 women aged 17–45 with confirmed TS (12 GH-treated) agreed to participate in this cross-sectional study. Dual X-ray absorptiometry (DXA) of lumbar spine, hip, and radius and high-resolution peripheral quantitative computed tomography (HR-pQCT) scans of the radius and tibia were used to determine standard morphological and micro-architectural parameters of bone health. Finite element (FE) analysis and polar moment of inertia (pMOI) were used to estimate bone strength. GH-treated subjects were +7.4 cm taller (95 % CI 2.5–12.3 cm, p  = 0.005). DXA-determined areal BMD of hip, spine, and radius was similar between treatment groups. Both tibial and radial total bone areas were greater among GH-treated subjects (+20.4 and +21.2 % respectively, p  
ISSN:0171-967X
1432-0827
DOI:10.1007/s00223-015-0064-8