Enhanced immune activation linked to endotoxemia in HIV-1 seronegative MSM

This study assessed cellular and soluble markers of immune activation in HIV-1 seronegative MSM. MSM immune profiles were characterized by an increased expression of CD57 on T cells and endotoxemia. Endotoxin presence was linked to recent high-risk exposure and associated with elevated cytokine leve...

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Veröffentlicht in:	AIDS (London) 2014-09, Vol.28 (14), p.2162-2166
Hauptverfasser:	Palmer, Christine D, Tomassilli, Julia, Sirignano, Michael, Romero-Tejeda, Marisol, Arnold, Kelly B, Che, Denise, Lauffenburger, Douglas A, Jost, Stephanie, Allen, Todd, Mayer, Kenneth H, Altfeld, Marcus
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV CD4-Positive T-Lymphocytes - immunology CD57 Antigens - immunology CD8-Positive T-Lymphocytes - immunology Endotoxemia - immunology HIV Seronegativity - immunology HIV-1 - immunology Homosexuality, Male - statistics & numerical data Human immunodeficiency virus 1 Humans Immunity, Cellular - immunology Lentivirus Lymphocyte Activation - immunology Male T-Lymphocytes, Cytotoxic - immunology
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Beschreibung
Zusammenfassung:	This study assessed cellular and soluble markers of immune activation in HIV-1 seronegative MSM. MSM immune profiles were characterized by an increased expression of CD57 on T cells and endotoxemia. Endotoxin presence was linked to recent high-risk exposure and associated with elevated cytokine levels and decreased CD4+/CD8+ T cell ratios. Taken together, these data show elevated levels of inflammation linked to periods of endotoxemia resulting in a significantly different immune phenotype in a subset of MSM at a high risk of HIV-1 acquisition.
ISSN:	0269-9370 1473-5571
DOI:	10.1097/QAD.0000000000000386