Grape-seed proanthocyanidins inhibit the lipopolysaccharide-induced inflammatory mediator expression in RAW264.7 macrophages by suppressing MAPK and NF-κb signal pathways

Highlights • LPS was used to induced inflammatory reaction in RAW264.7 macrophages. • Grape seed proanthocyanidins suppressed the mRNA level of inflammatory mediators. • Grape seed proanthocyanidins suppressed the secretion of inflammatory mediators. • GSPs treatment inhibited the nuclear factor-κB...

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Veröffentlicht in:	Environmental toxicology and pharmacology 2016-01, Vol.41, p.159-166
Hauptverfasser:	Chu, Hongqian, Tang, Qiuqiong, Huang, Hongpeng, Hao, Weidong, Wei, Xuetao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Cell Line Cell Proliferation - genetics Cell Survival - drug effects Cytokines Cytokines - genetics Emergency Gene Expression Regulation - drug effects Grape Seed Extract - pharmacology Grape-seed proanthocyanidins Lipopolysaccharides - adverse effects Macrophages - cytology Macrophages - drug effects Macrophages - immunology MAP Kinase Signaling System - drug effects MAPK Mice NF-kappa B - genetics NF-κb Proanthocyanidins - pharmacology
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Zusammenfassung:	Highlights • LPS was used to induced inflammatory reaction in RAW264.7 macrophages. • Grape seed proanthocyanidins suppressed the mRNA level of inflammatory mediators. • Grape seed proanthocyanidins suppressed the secretion of inflammatory mediators. • GSPs treatment inhibited the nuclear factor-κB and MAPK signal pathways.
ISSN:	1382-6689 1872-7077
DOI:	10.1016/j.etap.2015.11.018