Evaluation of the Antiangiogenic Effects of Octreotide on Growth Hormone-producing Pituitary Adenoma using Arterial Spin-labeling Perfusion Imaging

Decreased absolute tumor blood flow (TBF) measured by arterial spin labeling perfusion imaging (ASL-PI) on 3-tesla magnetic resonance imaging demonstrated the reduced size and growth hormone (GH) secretion of a large GH-producing pituitary adenoma in a 32-year-old man in response to octreotide thera...

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Veröffentlicht in:	Magnetic Resonance in Medical Sciences 2015/02/01, Vol.14(1), pp.73-76
Hauptverfasser:	SAKAI, Naoto, YAMASHITA, Shuhei, TAKEHARA, Yasuo, SAKAHARA, Harumi, BABA, Satoshi, OKI, Yutaka, TAKAHASHI, Goro, KOIZUMI, Shinichiro, SAMESHIMA, Tetsuro, NAMBA, Hiroki
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult angiogenesis Angiogenesis Inhibitors - pharmacology Antineoplastic Agents, Hormonal - pharmacology arterial spin-labeling (ASL) Human Growth Hormone - secretion Humans magnetic resonance Magnetic Resonance Imaging Male octreotide Octreotide - pharmacology pituitary adenoma Pituitary Neoplasms - blood supply Pituitary Neoplasms - drug therapy Pituitary Neoplasms - secretion Reproducibility of Results Spin Labels
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Zusammenfassung:	Decreased absolute tumor blood flow (TBF) measured by arterial spin labeling perfusion imaging (ASL-PI) on 3-tesla magnetic resonance imaging demonstrated the reduced size and growth hormone (GH) secretion of a large GH-producing pituitary adenoma in a 32-year-old man in response to octreotide therapy. The study shows the usefulness of ASL-PI in providing a biomarker of the antiangiogenic effect of octreotide.
ISSN:	1347-3182 1880-2206
DOI:	10.2463/mrms.2014-0026