Type VI secretion and anti-host effectors

Highlights • T6SS is a secretion system involved in the virulence of bacterial pathogens. • This versatile weapon can target both prokaryotic and eukaryotic cells. • The T6SS tail/spike displays a high modularity for toxin and effector delivery. • The repertoire of T6SS anti-host effectors is used t...

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Veröffentlicht in:	Current opinion in microbiology 2016-02, Vol.29, p.81-93
Hauptverfasser:	Hachani, Abderrahman, Wood, Thomas E, Filloux, Alain
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiosis Bacteria - pathogenicity Bacterial Infections - immunology Bacterial Infections - microbiology Bacterial Proteins - metabolism Gastrointestinal Tract - microbiology Host-Pathogen Interactions Humans Immune Evasion Mice Pathology Protein Transport Symbiosis Type VI Secretion Systems - genetics Type VI Secretion Systems - physiology Virulence Factors - genetics Virulence Factors - physiology
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Beschreibung
Zusammenfassung:	Highlights • T6SS is a secretion system involved in the virulence of bacterial pathogens. • This versatile weapon can target both prokaryotic and eukaryotic cells. • The T6SS tail/spike displays a high modularity for toxin and effector delivery. • The repertoire of T6SS anti-host effectors is used to evade and subvert host defense mechanisms. • T6SS anti-host activity is coordinated with other bacterial virulence factors.
ISSN:	1369-5274 1879-0364
DOI:	10.1016/j.mib.2015.11.006