Radical Fluoroalkylation of Isocyanides with Fluorinated Sulfones by Visible-Light Photoredox Catalysis

The radical fluoroalkylation of isocyanides with fluorinated sulfones is enabled by visible‐light photoredox catalysis. A wide range of readily available mono‐, di‐, and trifluoromethyl heteroaryl sulfones can thus be used as efficient radical fluoroalkylation reagents under mild conditions. This method not only describes a new synthetic application of fluorinated sulfones, but also provides a new route to fluoroalkyl radicals. Sulfones in the spotlight: The radical fluoroalkylation of isocyanides with a wide range of readily available mono‐, di‐, and trifluoromethyl heteroaryl sulfones is enabled by visible‐light photoredox catalysis. Fluorinated sulfones can thus be used as precursors of fluoroalkyl radicals.