Bioactive cyclolanstane-type saponins from the stems of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao

Twelve cyclolanstane-type saponins including six new ones, astrolanosaponins A₁ (1), A₂ (2), B (3), C (4), D (5), and E (6) were obtained from the stem of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao, and their structures were elucidated by chemical and spectroscopic methods....

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Veröffentlicht in:Journal of natural medicines 2016-04, Vol.70 (2), p.198-206
Hauptverfasser: Wang, Tingting, Ruan, Jingya, Li, Xiaoxia, Chao, Liping, Shi, Pingping, Han, Lifeng, Zhang, Yi, Wang, Tao
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Sprache:eng
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Zusammenfassung:Twelve cyclolanstane-type saponins including six new ones, astrolanosaponins A₁ (1), A₂ (2), B (3), C (4), D (5), and E (6) were obtained from the stem of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao, and their structures were elucidated by chemical and spectroscopic methods. Of the known ones, cycloastragenol-3-O-β-D-glucopyranoside (7), astraverrucin II (8), cycloaraloside E (9), huangqiyenin A (10), and huangqiyenin B (11) were isolated from the species first. Meanwhile, compounds 1–3, 5–9, and aleksandroside I (12) showed inhibitory effects on triglyceride accumulation in HepG2 cells.
ISSN:1340-3443
1861-0293
DOI:10.1007/s11418-015-0959-8