Bioactive cyclolanstane-type saponins from the stems of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao
Twelve cyclolanstane-type saponins including six new ones, astrolanosaponins A₁ (1), A₂ (2), B (3), C (4), D (5), and E (6) were obtained from the stem of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao, and their structures were elucidated by chemical and spectroscopic methods....
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Veröffentlicht in: | Journal of natural medicines 2016-04, Vol.70 (2), p.198-206 |
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Sprache: | eng |
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Zusammenfassung: | Twelve cyclolanstane-type saponins including six new ones, astrolanosaponins A₁ (1), A₂ (2), B (3), C (4), D (5), and E (6) were obtained from the stem of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao, and their structures were elucidated by chemical and spectroscopic methods. Of the known ones, cycloastragenol-3-O-β-D-glucopyranoside (7), astraverrucin II (8), cycloaraloside E (9), huangqiyenin A (10), and huangqiyenin B (11) were isolated from the species first. Meanwhile, compounds 1–3, 5–9, and aleksandroside I (12) showed inhibitory effects on triglyceride accumulation in HepG2 cells. |
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ISSN: | 1340-3443 1861-0293 |
DOI: | 10.1007/s11418-015-0959-8 |