Studies on the synthesis of N super(G)-nitro-L-arginine derivatives and their effects on septic shock

Studies on the synthesis of N super(G)-nitro-L-arginine derivatives and their effects on septic shock

(HCl times N super(G) - NO sub(2) - Arg) sub(2) Lys - OCH sub(3), (HCl times N super(G) - NO sub(2) - Arg) sub(2)Lys - OH, [(HCl times N super(G) - NO sub(2) - Arg) sub(2)Lys] sub(2)Lys - OCH sub(3), and [(HCl times N super(G) - NO sub(2)-Arg) sub(2)Lys] sub(2)Lys-OH were synthesized by use of a sol...

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Veröffentlicht in:Preparative biochemistry & biotechnology 2000-08, Vol.30 (3), p.241-246
Hauptverfasser: Ming, Zhao, Chao, Wang, Mingdi, Gu, Shiqi, Peng, Junke, Yang, Kexiang, Zhou, Saizhu, Wu
Format: Artikel
Sprache:eng
Schlagworte:
NG-nitro-L-arginine
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Zusammenfassung:(HCl times N super(G) - NO sub(2) - Arg) sub(2) Lys - OCH sub(3), (HCl times N super(G) - NO sub(2) - Arg) sub(2)Lys - OH, [(HCl times N super(G) - NO sub(2) - Arg) sub(2)Lys] sub(2)Lys - OCH sub(3), and [(HCl times N super(G) - NO sub(2)-Arg) sub(2)Lys] sub(2)Lys-OH were synthesized by use of a solution method. Their effect on septic shock was studied in vivo. The results indicate that increasing the number of N super(G)-NO sub(2)-Arg residues in a molecule may be useful to improve the response to septic shock.
ISSN:1082-6068