Use of a functional cell mediated immunity assay for monitoring reduction of immunosupression in transplant BK virus nephropathy

Use of a functional cell mediated immunity assay for monitoring reduction of immunosupression in transplant BK virus nephropathy

Polyoma or BK virus nephropathy may lead to impaired renal function after transplantation. This opportunistic infection is a surrogate marker for over immunosuppression. Treatment consists of reduction in immunosuppression (IS); however, this increases the risk of acute allograft rejection. Recently...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of neurovirology 2005-01, Vol.11
Hauptverfasser: Gautam, A, Fischer, SA, Yango, A F, Gohh, R Y, Morrissey, P E, Monaco, AP
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Polyoma or BK virus nephropathy may lead to impaired renal function after transplantation. This opportunistic infection is a surrogate marker for over immunosuppression. Treatment consists of reduction in immunosuppression (IS); however, this increases the risk of acute allograft rejection. Recently we have estimated global immunosuppression by measuring ATP activity in stimulated CD4(+) cells(Immuknow-Cylex Inc). This assay serves as a marker of cell-mediated immunity. High levels (>525 ATP ng/ml) correspond to robust immunity and carry a heightened risk of acute rejection, while low levels (
ISSN:1355-0284