Emergence of influenza A (H1N1)pdm09 genogroup 6B and drug resistant virus, India, January to May 2015

To investigate the aetiology of the 2015 A(H1N1)pdm09 influenza outbreak in India, 1,083 nasopharyngeal swabs from suspect patients were screened for influenza A(H1N1)pdm09 in the state of Madhya Pradesh. Of 412 positive specimens, six were further characterised by phylogenetic analysis of haemagglu...

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Veröffentlicht in:	Euro surveillance : bulletin européen sur les maladies transmissibles 2016-02, Vol.21 (5), p.6-11
Hauptverfasser:	Parida, Manmohan, Dash, Paban Kumar, Kumar, Jyoti S, Joshi, Gaurav, Tandel, Kundan, Sharma, Shashi, Srivastava, Ambuj, Agarwal, Ankita, Saha, Amrita, Saraswat, Shweta, Karothia, Divyanshi, Malviya, Vatsala
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Antiviral Agents - therapeutic use Child Child, Preschool Disease Outbreaks Drug resistance Epidemics Genes Genotype Hemagglutinin Glycoproteins, Influenza Virus - genetics Humans India - epidemiology Infant Infant, Newborn Influenza Influenza A Virus, H1N1 Subtype - genetics Influenza A Virus, H1N1 Subtype - isolation & purification Influenza, Human - diagnosis Influenza, Human - epidemiology Influenza, Human - virology Middle Aged Molecular Sequence Data Mutation Nasopharynx - virology Neuraminidase - genetics Oseltamivir - therapeutic use Phylogenetics Phylogeny Population Surveillance Reverse Transcriptase Polymerase Chain Reaction Sequence Analysis, DNA Young Adult
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Zusammenfassung:	To investigate the aetiology of the 2015 A(H1N1)pdm09 influenza outbreak in India, 1,083 nasopharyngeal swabs from suspect patients were screened for influenza A(H1N1)pdm09 in the state of Madhya Pradesh. Of 412 positive specimens, six were further characterised by phylogenetic analysis of haemagglutinin (HA) sequences revealing that they belonged to genogroup 6B. A new mutation (E164G) was observed in HA2 of two sequences. Neuraminidase genes in two of 12 isolates from fatal cases on prior oseltamivir treatment harboured the H275Y mutation.
ISSN:	1560-7917 1025-496X 1560-7917
DOI:	10.2807/1560-7917.ES.2016.21.5.30124