P53 and Bax implication in NMDA induced-apoptosis in mouse hippocampus

Seven days after in vivo intrahippocampal administration of NMDA, 3′-OH DNA fragmentations and Bax protein expression were detected in hippocampal neurons of p53+/+ but not p53−/− transgenic mice. Interestingly, neurons showing pycnosis, an early apoptotic phenomena, were present in all genotypes. T...

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Veröffentlicht in:	Neuroreport 2000-09, Vol.11 (13), p.2973-2976
Hauptverfasser:	Djebaïli, Myriam, Rondouin, Gérard, Baille, Valérie, Bockaert, Joël
Format:	Artikel
Sprache:	eng
Schlagworte:	Ageing, cell death Animals Apoptosis - drug effects Apoptosis - physiology bcl-2-Associated X Protein Biological and medical sciences Cell physiology DNA Fragmentation - drug effects DNA Fragmentation - physiology Fundamental and applied biological sciences. Psychology Hippocampus - drug effects Hippocampus - metabolism Hippocampus - pathology Mice Mice, Knockout Molecular and cellular biology N-Methyl-D-aspartic acid N-Methylaspartate - toxicity Nerve Degeneration - chemically induced Nerve Degeneration - metabolism Nerve Degeneration - pathology Neurons - drug effects Neurons - metabolism Proto-Oncogene Proteins - drug effects Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-bcl-2 pycnosis Tumor Suppressor Protein p53 - deficiency Tumor Suppressor Protein p53 - genetics
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Zusammenfassung:	Seven days after in vivo intrahippocampal administration of NMDA, 3′-OH DNA fragmentations and Bax protein expression were detected in hippocampal neurons of p53+/+ but not p53−/− transgenic mice. Interestingly, neurons showing pycnosis, an early apoptotic phenomena, were present in all genotypes. These results confirm that apoptotic 3′OH DNA fragmentations and Bax protein induction during NMDA-induced apoptosis in adult hippocampal neurons are p53 dependent.
ISSN:	0959-4965 1473-558X
DOI:	10.1097/00001756-200009110-00029