METABOLIC PROCESSES OF ORGANISM IN REMOTE PERIOD AFTER THE COMBINED EFFECTS OF RADIATION AND EMOTIONAL STRESS

Aim of the research was to study the role of free radical oxidation in the tissues of adrenal and immune organs and cells in remote period after combined effects of sublethal dose of gamma radiation (6 Gy) and emotional stress. Forty male Wistar rats were divided into four groups: I - control; II - exposed to emotional stress; III - exposed to radiation; IV - under the combined effects of emotional stress and radiation. Emotional stress in groups II and IV was simulated by tail suspension. In groups III and IV rats were irradiated once 90 days before the investigation at 6 Gy via TERAGAM Сo60 («ISOTREND spol. s.r.o.», Czech Republic). The results of study showed that after the long term exposure gamma radiation has inhibitory effect of the radiation factor in the antioxidant protection. Ionizing radiation combined with emotional stress in remote period has a more pronounced effect on the formation of lipid hyper peroxidation syndrome than separately. Influence of the combined effects of emotional stress and ionizing radiation resulted in increased levels of DC and MDA, inhibition of enzyme activity of catalase and glutathione reductase in almost all the study objects, resulting in the development of dual-oxidative stress.