Cranioplasty Using a Novel Osteoconductive Scaffold and Platelet Gel

BACKGROUNDCommonly used materials for cranioplasty include autogenous bone grafts, methyl methacrylate, and titanium mesh. We evaluated a novel osteoconductive scaffold [N-isopropylacrylamide cross-linked with acrylic acid using γ-rays (ANa powder)] mixed with platelet gel for cranioplasty. METHODSA...

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Veröffentlicht in:Annals of plastic surgery 2016-03, Vol.76 Suppl 1 (Supplement 1), p.S125-S129
Hauptverfasser: Tseng, Ching-Li, Chang, Guang-Wei, OU, Kuang-Ling, Chou, Wei-Ting, Wu, Te-Hsing, Fang, Hsu-Wei, Tsai, Jui-Che, Chen, Tim-Mo
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Sprache:eng
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Zusammenfassung:BACKGROUNDCommonly used materials for cranioplasty include autogenous bone grafts, methyl methacrylate, and titanium mesh. We evaluated a novel osteoconductive scaffold [N-isopropylacrylamide cross-linked with acrylic acid using γ-rays (ANa powder)] mixed with platelet gel for cranioplasty. METHODSANa powder mixed with platelet gel was implanted into a 15 × 15-mm, full-thickness calvarial bone defect in 5 New Zealand white rabbits. ANa powder mixed with phosphate-buffered saline was implanted in 5 rabbits. The calvarial bone defect was left unreconstructed in another 5 rabbits. Twelve weeks after surgery, computed tomography examination was used to evaluate the radiographic evidence of bone healing in vivo. Bone specimens were then retrieved for histologic study. RESULTSThe ANa scaffold mixed with platelet gel is biocompatible, biodegradable, and both osteoconductive and osteoinductive, leading to progressive growth of new bone into the calvarial bone defect. CONCLUSIONThe use of this novel osteoconductive scaffold combined with osteoinductive platelet gel offers a valuable alternative for the reconstruction of calvarial bone defects.
ISSN:0148-7043
1536-3708
DOI:10.1097/SAP.0000000000000696