Dynamic nuclear polarization of biocompatible (13)C-enriched carbonates for in vivo pH imaging

A hyperpolarization technique using carbonate precursors of biocompatible molecules was found to yield high concentrations of hyperpolarized (13)C bicarbonate in solution. This approach enabled large signal gains for low-toxicity hyperpolarized (13)C pH imaging in a phantom and in vivo in a murine m...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2016-02, Vol.52 (14), p.3030-3033
Hauptverfasser:	Korenchan, D E, Flavell, R R, Baligand, C, Sriram, R, Neumann, K, Sukumar, S, VanBrocklin, H, Vigneron, D B, Wilson, D M, Kurhanewicz, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Biocompatible Materials Carbon Isotopes - chemistry Carbon-13 Magnetic Resonance Spectroscopy Hydrogen-Ion Concentration
Online-Zugang:	Volltext
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Zusammenfassung:	A hyperpolarization technique using carbonate precursors of biocompatible molecules was found to yield high concentrations of hyperpolarized (13)C bicarbonate in solution. This approach enabled large signal gains for low-toxicity hyperpolarized (13)C pH imaging in a phantom and in vivo in a murine model of prostate cancer.
ISSN:	1364-548X
DOI:	10.1039/c5cc09724j