Petrosamine B, an Inhibitor of the Helicobacter pylori Enzyme Aspartyl Semialdehyde Dehydrogenase from the Australian Sponge Oceanapia sp

Bioassay-guided fractionation of the MeOH extract of the sponge Oceanapia sp. using the Helicobacter pylori enzyme, aspartyl semialdehyde dehydrogenase, ASD, to detect antibacterial activity, led to the isolation of a new pyridoacridine alkaloid, petrosamine B (1). Petrosamine B is a bright blue com...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2005-05, Vol.68 (5), p.804-806
Hauptverfasser:	CARROLL, Anthony R., NGO, Anna, QUINN, Ronald J., REDBURN, Joanne, HOOPER, John N. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acridines - chemistry Acridines - isolation & purification Acridines - pharmacology Aldehyde Dehydrogenase - antagonists & inhibitors Alkaloids - chemistry Alkaloids - isolation & purification Alkaloids - pharmacology Animals Australia Bacterial Proteins - antagonists & inhibitors Biological and medical sciences Enzyme Inhibitors - chemistry Enzyme Inhibitors - isolation & purification Enzyme Inhibitors - pharmacology General pharmacology Helicobacter pylori - enzymology Inhibitory Concentration 50 Marine Medical sciences Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phenanthrenes - chemistry Phenanthrenes - isolation & purification Phenanthrenes - pharmacology Porifera - chemistry
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Zusammenfassung:	Bioassay-guided fractionation of the MeOH extract of the sponge Oceanapia sp. using the Helicobacter pylori enzyme, aspartyl semialdehyde dehydrogenase, ASD, to detect antibacterial activity, led to the isolation of a new pyridoacridine alkaloid, petrosamine B (1). Petrosamine B is a bright blue compound that is sparingly soluble in many organic solvents. The structure of 1 was determined from detailed NMR studies performed in TFA/D2O. Petrosamine B was found to be a weak inhibitor of ASD with an IC50 of 306 microM.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np049595s