Outside-in? Acute fetal systemic inflammation in very preterm chronically catheterized sheep fetuses is not driven by cells in the fetal blood

Background The preterm birth syndrome (delivery before 37 weeks gestation) is a major contributor to the global burden of perinatal morbidity and death. The cause of preterm birth is complex, multifactorial, and likely dependent, at least in part, on the gestational age of the fetus. Intrauterine in...

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Veröffentlicht in:	American journal of obstetrics and gynecology 2016-02, Vol.214 (2), p.281.e1-281.e10
Hauptverfasser:	Kemp, Matthew W., PhD, Molloy, Timothy J., PhD, Usuda, Haruo, MD, Woodward, Eleanor, PhD, Miura, Yuichiro, PhD, Payne, Matthew S., PhD, Ireland, Demelza J., PhD, Jobe, Alan H., PhD, Kallapur, Suhas G., PhD, Stock, Sarah J., PhD, Spiller, Owen B., PhD, Newnham, John P., MD, Saito, Masatoshi, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Amniotic Fluid Animals Catheterization Catheterization, Central Venous Cell Proliferation - drug effects Chemokine CCL8 - drug effects Chemokine CCL8 - genetics Chemokine CCL8 - immunology Cytokines - drug effects Cytokines - genetics Cytokines - immunology Disease Models, Animal Enzyme-Linked Immunosorbent Assay Escherichia coli Female Fetal Blood - immunology Fetal Diseases - immunology fetus Fetus - drug effects Fetus - immunology infection Inflammation Interleukin-10 - genetics Interleukin-10 - immunology Interleukin-1beta - drug effects Interleukin-1beta - genetics Interleukin-1beta - immunology Interleukin-6 - genetics Interleukin-6 - immunology Interleukin-8 - drug effects Interleukin-8 - genetics Interleukin-8 - immunology Lipopolysaccharides - pharmacology Obstetrics and Gynecology Polymerase Chain Reaction Pregnancy preterm birth RNA, Messenger - immunology RNA, Messenger - metabolism Sheep Systemic Inflammatory Response Syndrome - immunology Tissue Array Analysis Trachea Tumor Necrosis Factor-alpha - drug effects Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - immunology Up-Regulation
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Zusammenfassung:	Background The preterm birth syndrome (delivery before 37 weeks gestation) is a major contributor to the global burden of perinatal morbidity and death. The cause of preterm birth is complex, multifactorial, and likely dependent, at least in part, on the gestational age of the fetus. Intrauterine infection is frequent in preterm deliveries that occur at
ISSN:	0002-9378 1097-6868
DOI:	10.1016/j.ajog.2015.09.076