Therapeutic drug monitoring of cerebrospinal fluid vancomycin concentration during intraventricular administration

Therapeutic drug monitoring of cerebrospinal fluid vancomycin concentration during intraventricular administration

Summary Limited data are available on intraventricular vancomycin dosing for meningitis. This study explored clinical characteristics that correlated with cerebrospinal fluid (CSF) concentrations. Over a nine-year period, 13 patients with 34 CSF vancomycin concentrations were evaluated. CSF output a...

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Veröffentlicht in:The Journal of hospital infection 2016-02, Vol.92 (2), p.199-202
Hauptverfasser: Popa, D, Loewenstein, L, Lam, S.W, Neuner, E.A, Ahrens, C.L, Bhimraj, A
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents - analysis
Anti-Bacterial Agents - pharmacokinetics
Cerebrospinal Fluid - chemistry
Drug Monitoring
Female
Humans
Infectious Disease
Injections, Intraventricular
Intraventricular
Male
Meningitis
Meningitis, Bacterial - drug therapy
Middle Aged
Retrospective Studies
Therapeutic drug monitoring
Vancomycin
Vancomycin - analysis
Vancomycin - pharmacokinetics
Ventriculitis
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Beschreibung
Zusammenfassung:Summary Limited data are available on intraventricular vancomycin dosing for meningitis. This study explored clinical characteristics that correlated with cerebrospinal fluid (CSF) concentrations. Over a nine-year period, 13 patients with 34 CSF vancomycin concentrations were evaluated. CSF output and time from dose correlated with CSF vancomycin concentration. No relationship was seen with regards to CSF protein, white blood cell count or glucose.
ISSN:0195-6701
1532-2939
DOI:10.1016/j.jhin.2015.10.017