Interrogating Circulating Microsomes and Exosomes Using Metal Nanoparticles

Interrogating Circulating Microsomes and Exosomes Using Metal Nanoparticles

A chip‐based approach for electrochemical characterization and detection of microsomes and exosomes based on direct electro‐oxidation of metal nanoparticles (MNPs) that specifically recognize surface markers of these vesicles is reported. It is found that exosomes and microsomes derived from prostat...

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Veröffentlicht in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2016-02, Vol.12 (6), p.727-732
Hauptverfasser: Zhou, Yi-Ge, Mohamadi, Reza M., Poudineh, Mahla, Kermanshah, Leyla, Ahmed, Sharif, Safaei, Tina Saberi, Stojcic, Jessica, Nam, Robert K., Sargent, Edward H., Kelley, Shana O.
Format: Artikel
Sprache:eng
Schlagworte:
Cell Line, Tumor
Electrochemistry
exosomes
Exosomes - metabolism
Exosomes - ultrastructure
Humans
Male
Metal Nanoparticles - chemistry
microsomes
Microsomes - metabolism
Microsomes - ultrastructure
nanoparticles
Nanotechnology
prostate cancer
Prostatic Neoplasms - blood
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Zusammenfassung:A chip‐based approach for electrochemical characterization and detection of microsomes and exosomes based on direct electro‐oxidation of metal nanoparticles (MNPs) that specifically recognize surface markers of these vesicles is reported. It is found that exosomes and microsomes derived from prostate cancer cells can be identified by their surface proteins EpCAM and PSMA, suggesting the potential of exosomes and microsomes for use as diagnostic biomarkers.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.201502365