Organoselenium-Catalyzed Synthesis of Oxygen- and Nitrogen-Containing Heterocycles

Organoselenium-Catalyzed Synthesis of Oxygen- and Nitrogen-Containing Heterocycles

A new and efficient approach for the synthesis of oxygen and nitrogen heterocycles by organoselenium catalysis has been developed. The exo-cyclization proceeded smoothly under mild conditions with good functional group tolerance and excellent regioselectivity. Mechanistic studies revealed that 1-flu...

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Veröffentlicht in:Organic letters 2016-02, Vol.18 (3), p.504-507
Hauptverfasser: Guo, Ruizhi, Huang, Jiachen, Huang, Haiyan, Zhao, Xiaodan
Format: Artikel
Sprache:eng
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Zusammenfassung:A new and efficient approach for the synthesis of oxygen and nitrogen heterocycles by organoselenium catalysis has been developed. The exo-cyclization proceeded smoothly under mild conditions with good functional group tolerance and excellent regioselectivity. Mechanistic studies revealed that 1-fluoropyridinium triflate is key for oxidative cyclization.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.5b03543