Vitamin B12 supplementation during pregnancy and postpartum improves B12 status of both mothers and infants but vaccine response in mothers only: a randomized clinical trial in Bangladesh

PURPOSE: Poor vitamin B12 (B12) status is associated with adverse outcomes in pregnancy and infancy. Little is known about effects of B12 supplementation on immune function. The present study aimed to evaluate effects of pre- and postnatal B12 supplementation on biomarkers of B12 status and vaccine-...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of nutrition 2016-02, Vol.55 (1), p.281-293
Hauptverfasser:	Siddiqua, Towfida J, Ahmad, Shaikh M, Ahsan, Khalid B, Rashid, Mamunur, Roy, Anjan, Rahman, Syed M, Shahab-Ferdows, Setareh, Hampel, Daniela, Ahmed, Tahmeed, Allen, Lindsay H, Raqib, Rubhana
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult antibodies Bangladesh biomarkers Biomarkers - blood blood serum breast milk C-reactive protein C-Reactive Protein - metabolism Chemistry Chemistry and Materials Science colostrum Dietary Supplements Dose-Response Relationship, Drug Female ferritin Ferritins - blood folic acid Folic Acid - administration & dosage Folic Acid - blood glycoproteins hemoglobin Hemoglobins - metabolism homocysteine Homocysteine - blood Humans immunoglobulin A Immunoglobulin A - blood infancy Infant inflammation influenza Influenza A Virus, H1N1 Subtype Influenza Vaccines - immunology Influenza, Human - prevention & control Lactation Maternal Nutritional Physiological Phenomena methylmalonic acid Methylmalonic Acid - blood Milk, Human mothers neonates Nutrition Original Contribution Orosomucoid - metabolism pandemic placebos Postpartum Period - drug effects Postpartum Period - metabolism Pregnancy pregnancy outcome randomized clinical trials Receptors, Transferrin - blood transferrin vaccines Vitamin B 12 - administration & dosage Vitamin B 12 - blood vitamin B12 women Young Adult
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	PURPOSE: Poor vitamin B12 (B12) status is associated with adverse outcomes in pregnancy and infancy. Little is known about effects of B12 supplementation on immune function. The present study aimed to evaluate effects of pre- and postnatal B12 supplementation on biomarkers of B12 status and vaccine-specific responses in mothers and infants. METHOD: In a blinded, placebo-controlled trial, Bangladeshi women (n = 68, age 18–35 years, hemoglobin 10 μmol/L). Supplementation increased B12 in plasma, colostrums and breast milk (p
ISSN:	1436-6207 1436-6215
DOI:	10.1007/s00394-015-0845-x