Evaluation of liposomal nanocarriers loaded with ETB receptor agonist, IRL-1620, using cell-based assays
Highlights • PEGylated liposomes encapsulating IRL-1620 were successfully prepared and characterized. • Increased cell viability of differentiated PC-12 cells in liposomal IRL-1620 vs. free IRL-1620. • IRL-1620 found to induce neurite development in neuronal PC-12 cells model. • Increased BCL-2 and...
Gespeichert in:
| Veröffentlicht in: | Neuroscience 2016-01, Vol.312, p.141-152 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 152 |
|---|---|
| container_issue | |
| container_start_page | 141 |
| container_title | Neuroscience |
| container_volume | 312 |
| creator | Joshi, M.D Oesterling, B.M Wu, C Gwizdz, N Pais, G Briyal, S Gulati, A |
| description | Highlights • PEGylated liposomes encapsulating IRL-1620 were successfully prepared and characterized. • Increased cell viability of differentiated PC-12 cells in liposomal IRL-1620 vs. free IRL-1620. • IRL-1620 found to induce neurite development in neuronal PC-12 cells model. • Increased BCL-2 and decreased BAX expression in differentiated PC-12 cells by liposomal IRL-1620. |
| doi_str_mv | 10.1016/j.neuroscience.2015.11.016 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1762380778</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0306452215010052</els_id><sourcerecordid>1751996897</sourcerecordid><originalsourceid>FETCH-LOGICAL-c468t-7fcfba7402b1a0f92798a970770dbedd57553785f2ccca75f80df4297d8ded5b3</originalsourceid><addsrcrecordid>eNqNUk1v1DAUtBCILoW_gCxOHJrg58RxwgEJygKVVkKCcrYcf7RevPbWTor23-NoF4Q41Rcf3sy80cxD6BWQGgh0b7Z1MHOKWTkTlKkpAVYD1GX0CK2g503FWds-RivSkK5qGaVn6FnOW1Iea5un6Ix2bKCcwgrdru-ln-XkYsDRYu_2Mced9DjIEJVMyZmUsY9SG41_uekWr68_4GSU2U8xYXkTg8vTBb76tqmgo-QCz9mFG6yM99Uoc2HJnOUhP0dPrPTZvDj95-jHp_X15Zdq8_Xz1eX7TaXarp8qbpUdJW8JHUESW1wOvRw44Zzo0WjNOGMN75mlSinJme2Jti0duO6LQzY25-j1UXef4t1s8iR2Li9uZDBxzgJ4R5u-6PUPgDIYhq4feIG-PUJVyT0nY8U-uZ1MBwFELKWIrfi3FLGUIgBEGRXyy9OeedwZ_Zf6p4UC-HgEmBLMfUlcnGS0K0lPQkf3sD3v_pNR3gWnpP9pDiZv45xCiV6AyFQQ8X05j-U6gBEol0Gb32aXuVQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1751996897</pqid></control><display><type>article</type><title>Evaluation of liposomal nanocarriers loaded with ETB receptor agonist, IRL-1620, using cell-based assays</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Joshi, M.D ; Oesterling, B.M ; Wu, C ; Gwizdz, N ; Pais, G ; Briyal, S ; Gulati, A</creator><creatorcontrib>Joshi, M.D ; Oesterling, B.M ; Wu, C ; Gwizdz, N ; Pais, G ; Briyal, S ; Gulati, A</creatorcontrib><description>Highlights • PEGylated liposomes encapsulating IRL-1620 were successfully prepared and characterized. • Increased cell viability of differentiated PC-12 cells in liposomal IRL-1620 vs. free IRL-1620. • IRL-1620 found to induce neurite development in neuronal PC-12 cells model. • Increased BCL-2 and decreased BAX expression in differentiated PC-12 cells by liposomal IRL-1620.</description><identifier>ISSN: 0306-4522</identifier><identifier>EISSN: 1873-7544</identifier><identifier>DOI: 10.1016/j.neuroscience.2015.11.016</identifier><identifier>PMID: 26592721</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>Animals ; Biological Assay ; Cell Survival ; Endothelins - administration & dosage ; Endothelins - pharmacology ; ETB receptor agonist ; IRL-1620 ; Liposomes ; Nanotechnology - methods ; Neurology ; Neurons - drug effects ; PC-12 cells ; PC12 Cells ; PEGylated liposomes ; Peptide Fragments - administration & dosage ; Peptide Fragments - pharmacology ; Polyethylene Glycols ; Rats ; Receptor, Endothelin B - agonists</subject><ispartof>Neuroscience, 2016-01, Vol.312, p.141-152</ispartof><rights>IBRO</rights><rights>2015 IBRO</rights><rights>Copyright © 2015 IBRO. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468t-7fcfba7402b1a0f92798a970770dbedd57553785f2ccca75f80df4297d8ded5b3</citedby><cites>FETCH-LOGICAL-c468t-7fcfba7402b1a0f92798a970770dbedd57553785f2ccca75f80df4297d8ded5b3</cites><orcidid>0000-0002-6358-0896 ; 0000-0002-0280-0349</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neuroscience.2015.11.016$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26592721$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Joshi, M.D</creatorcontrib><creatorcontrib>Oesterling, B.M</creatorcontrib><creatorcontrib>Wu, C</creatorcontrib><creatorcontrib>Gwizdz, N</creatorcontrib><creatorcontrib>Pais, G</creatorcontrib><creatorcontrib>Briyal, S</creatorcontrib><creatorcontrib>Gulati, A</creatorcontrib><title>Evaluation of liposomal nanocarriers loaded with ETB receptor agonist, IRL-1620, using cell-based assays</title><title>Neuroscience</title><addtitle>Neuroscience</addtitle><description>Highlights • PEGylated liposomes encapsulating IRL-1620 were successfully prepared and characterized. • Increased cell viability of differentiated PC-12 cells in liposomal IRL-1620 vs. free IRL-1620. • IRL-1620 found to induce neurite development in neuronal PC-12 cells model. • Increased BCL-2 and decreased BAX expression in differentiated PC-12 cells by liposomal IRL-1620.</description><subject>Animals</subject><subject>Biological Assay</subject><subject>Cell Survival</subject><subject>Endothelins - administration & dosage</subject><subject>Endothelins - pharmacology</subject><subject>ETB receptor agonist</subject><subject>IRL-1620</subject><subject>Liposomes</subject><subject>Nanotechnology - methods</subject><subject>Neurology</subject><subject>Neurons - drug effects</subject><subject>PC-12 cells</subject><subject>PC12 Cells</subject><subject>PEGylated liposomes</subject><subject>Peptide Fragments - administration & dosage</subject><subject>Peptide Fragments - pharmacology</subject><subject>Polyethylene Glycols</subject><subject>Rats</subject><subject>Receptor, Endothelin B - agonists</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUk1v1DAUtBCILoW_gCxOHJrg58RxwgEJygKVVkKCcrYcf7RevPbWTor23-NoF4Q41Rcf3sy80cxD6BWQGgh0b7Z1MHOKWTkTlKkpAVYD1GX0CK2g503FWds-RivSkK5qGaVn6FnOW1Iea5un6Ix2bKCcwgrdru-ln-XkYsDRYu_2Mced9DjIEJVMyZmUsY9SG41_uekWr68_4GSU2U8xYXkTg8vTBb76tqmgo-QCz9mFG6yM99Uoc2HJnOUhP0dPrPTZvDj95-jHp_X15Zdq8_Xz1eX7TaXarp8qbpUdJW8JHUESW1wOvRw44Zzo0WjNOGMN75mlSinJme2Jti0duO6LQzY25-j1UXef4t1s8iR2Li9uZDBxzgJ4R5u-6PUPgDIYhq4feIG-PUJVyT0nY8U-uZ1MBwFELKWIrfi3FLGUIgBEGRXyy9OeedwZ_Zf6p4UC-HgEmBLMfUlcnGS0K0lPQkf3sD3v_pNR3gWnpP9pDiZv45xCiV6AyFQQ8X05j-U6gBEol0Gb32aXuVQ</recordid><startdate>20160115</startdate><enddate>20160115</enddate><creator>Joshi, M.D</creator><creator>Oesterling, B.M</creator><creator>Wu, C</creator><creator>Gwizdz, N</creator><creator>Pais, G</creator><creator>Briyal, S</creator><creator>Gulati, A</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><orcidid>https://orcid.org/0000-0002-6358-0896</orcidid><orcidid>https://orcid.org/0000-0002-0280-0349</orcidid></search><sort><creationdate>20160115</creationdate><title>Evaluation of liposomal nanocarriers loaded with ETB receptor agonist, IRL-1620, using cell-based assays</title><author>Joshi, M.D ; Oesterling, B.M ; Wu, C ; Gwizdz, N ; Pais, G ; Briyal, S ; Gulati, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-7fcfba7402b1a0f92798a970770dbedd57553785f2ccca75f80df4297d8ded5b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Biological Assay</topic><topic>Cell Survival</topic><topic>Endothelins - administration & dosage</topic><topic>Endothelins - pharmacology</topic><topic>ETB receptor agonist</topic><topic>IRL-1620</topic><topic>Liposomes</topic><topic>Nanotechnology - methods</topic><topic>Neurology</topic><topic>Neurons - drug effects</topic><topic>PC-12 cells</topic><topic>PC12 Cells</topic><topic>PEGylated liposomes</topic><topic>Peptide Fragments - administration & dosage</topic><topic>Peptide Fragments - pharmacology</topic><topic>Polyethylene Glycols</topic><topic>Rats</topic><topic>Receptor, Endothelin B - agonists</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Joshi, M.D</creatorcontrib><creatorcontrib>Oesterling, B.M</creatorcontrib><creatorcontrib>Wu, C</creatorcontrib><creatorcontrib>Gwizdz, N</creatorcontrib><creatorcontrib>Pais, G</creatorcontrib><creatorcontrib>Briyal, S</creatorcontrib><creatorcontrib>Gulati, A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Joshi, M.D</au><au>Oesterling, B.M</au><au>Wu, C</au><au>Gwizdz, N</au><au>Pais, G</au><au>Briyal, S</au><au>Gulati, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of liposomal nanocarriers loaded with ETB receptor agonist, IRL-1620, using cell-based assays</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>2016-01-15</date><risdate>2016</risdate><volume>312</volume><spage>141</spage><epage>152</epage><pages>141-152</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><abstract>Highlights • PEGylated liposomes encapsulating IRL-1620 were successfully prepared and characterized. • Increased cell viability of differentiated PC-12 cells in liposomal IRL-1620 vs. free IRL-1620. • IRL-1620 found to induce neurite development in neuronal PC-12 cells model. • Increased BCL-2 and decreased BAX expression in differentiated PC-12 cells by liposomal IRL-1620.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>26592721</pmid><doi>10.1016/j.neuroscience.2015.11.016</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-6358-0896</orcidid><orcidid>https://orcid.org/0000-0002-0280-0349</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0306-4522 |
| ispartof | Neuroscience, 2016-01, Vol.312, p.141-152 |
| issn | 0306-4522 1873-7544 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1762380778 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Biological Assay Cell Survival Endothelins - administration & dosage Endothelins - pharmacology ETB receptor agonist IRL-1620 Liposomes Nanotechnology - methods Neurology Neurons - drug effects PC-12 cells PC12 Cells PEGylated liposomes Peptide Fragments - administration & dosage Peptide Fragments - pharmacology Polyethylene Glycols Rats Receptor, Endothelin B - agonists |
| title | Evaluation of liposomal nanocarriers loaded with ETB receptor agonist, IRL-1620, using cell-based assays |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T08%3A37%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Evaluation%20of%20liposomal%20nanocarriers%20loaded%20with%20ETB%20receptor%20agonist,%20IRL-1620,%20using%20cell-based%20assays&rft.jtitle=Neuroscience&rft.au=Joshi,%20M.D&rft.date=2016-01-15&rft.volume=312&rft.spage=141&rft.epage=152&rft.pages=141-152&rft.issn=0306-4522&rft.eissn=1873-7544&rft_id=info:doi/10.1016/j.neuroscience.2015.11.016&rft_dat=%3Cproquest_cross%3E1751996897%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1751996897&rft_id=info:pmid/26592721&rft_els_id=1_s2_0_S0306452215010052&rfr_iscdi=true |