Evaluation of liposomal nanocarriers loaded with ETB receptor agonist, IRL-1620, using cell-based assays

Highlights • PEGylated liposomes encapsulating IRL-1620 were successfully prepared and characterized. • Increased cell viability of differentiated PC-12 cells in liposomal IRL-1620 vs. free IRL-1620. • IRL-1620 found to induce neurite development in neuronal PC-12 cells model. • Increased BCL-2 and...

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Veröffentlicht in:	Neuroscience 2016-01, Vol.312, p.141-152
Hauptverfasser:	Joshi, M.D, Oesterling, B.M, Wu, C, Gwizdz, N, Pais, G, Briyal, S, Gulati, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Assay Cell Survival Endothelins - administration & dosage Endothelins - pharmacology ETB receptor agonist IRL-1620 Liposomes Nanotechnology - methods Neurology Neurons - drug effects PC-12 cells PC12 Cells PEGylated liposomes Peptide Fragments - administration & dosage Peptide Fragments - pharmacology Polyethylene Glycols Rats Receptor, Endothelin B - agonists
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Beschreibung
Zusammenfassung:	Highlights • PEGylated liposomes encapsulating IRL-1620 were successfully prepared and characterized. • Increased cell viability of differentiated PC-12 cells in liposomal IRL-1620 vs. free IRL-1620. • IRL-1620 found to induce neurite development in neuronal PC-12 cells model. • Increased BCL-2 and decreased BAX expression in differentiated PC-12 cells by liposomal IRL-1620.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.11.016