Response to immunization in children born to renal transplant recipients using immunosuppressive drugs during gestation

Highlights • Infants born to solid organ transplanted women are exposed to immunosuppression. • Eighty percent of infants born to renal transplant mothers had low B cells at birth. • Adequate humoral response to tetanus, Hib and pneumococcal vaccination was observed. • BCG healing was adequate and s...

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Veröffentlicht in:	Vaccine 2016-01, Vol.34 (4), p.404-407
Hauptverfasser:	Dinelli, Maria Isabel Saraiva, Ono, Erika, Viana, Patrícia Oliveira, Spina, Fernanda Garcia, Weckx, Lily Yin, dos Santos, Amélia Miyashiro Nunes, Moraes-Pinto, Maria Isabel de
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Allergy and Immunology Antibodies, Bacterial - blood B-Lymphocytes - cytology Bacterial Capsules Drugs Female Fetal Blood - cytology Gestation Haemophilus influenzae Haemophilus Vaccines - therapeutic use Hepatitis Humans Hypertension Immune response Immune system Immunity, Humoral Immunization Immunoglobulins Immunosuppression Immunosuppressive Agents - therapeutic use Infant Infant, Newborn Kidney Transplantation Lymphocytes Mothers Neonates Pediatrics Pneumococcal Vaccines - therapeutic use Pregnancy Pregnancy Complications - epidemiology Prenatal Exposure Delayed Effects - epidemiology Prospective Studies Solid organ transplantation Streptococcus infections Streptococcus pneumoniae Subpopulations Tetanus Transplant Recipients Transplants & implants Vaccination Vaccine Vaccines Young Adult
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Zusammenfassung:	Highlights • Infants born to solid organ transplanted women are exposed to immunosuppression. • Eighty percent of infants born to renal transplant mothers had low B cells at birth. • Adequate humoral response to tetanus, Hib and pneumococcal vaccination was observed. • BCG healing was adequate and similar to controls. • Local and systemic vaccine reactogenicity was similar to controls.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2015.12.017