Development of a high-yield reassortant influenza vaccine virus derived from the A/Anhui/1/2013 (H7N9) strain

Highlights • We have developed a 6:2 reassortant vaccine virus for avian influenza A (H7N9). • The original virus stock, A/Anhui/1/2013 (H7N9), was a quasi-species. • A125T of NIIDRG-10.1 HA might enhance the growth ability of the virus.

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Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2016-01, Vol.34 (3), p.328-333
Hauptverfasser:	Nakamura, Kazuya, Shirakura, Masayuki, Suzuki, Yasushi, Naito, Tadasuke, Fujisaki, Seiichiro, Tashiro, Masato, Nobusawa, Eri
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Amino acids Animals Antibodies, Viral - blood Avian influenza A (H7N9) virus Candidate vaccine virus Clinical Trials, Phase II as Topic Disease control Ferrets Genetics Hemagglutination Tests Humans Influenza Influenza A virus Influenza A Virus, H7N9 Subtype - genetics Influenza A Virus, H7N9 Subtype - immunology Influenza Vaccines - administration & dosage Influenza Vaccines - genetics Influenza Vaccines - immunology Influenza Vaccines - isolation & purification Japan Laboratories Mortality Mustela putorius furo Pandemics Plasmids Reassortant Viruses - genetics Reassortant Viruses - immunology Reverse Genetics Vaccines Viral quasi-species
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Beschreibung
Zusammenfassung:	Highlights • We have developed a 6:2 reassortant vaccine virus for avian influenza A (H7N9). • The original virus stock, A/Anhui/1/2013 (H7N9), was a quasi-species. • A125T of NIIDRG-10.1 HA might enhance the growth ability of the virus.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2015.11.050