Investigating brain functional evolution and plasticity using microelectrode array technology

Investigating brain functional evolution and plasticity using microelectrode array technology

Highlights • This work investigates plasticity in dissociated neuronal cultures on MEA grids. • Network response was measured after stimulating different grid quadrants. • There were no spatial differences in the stimulus-evoked activity within quadrants. • Depression was observed but decreased over...

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Veröffentlicht in:Brain research bulletin 2015-10, Vol.119 (Pt B), p.127-135
Hauptverfasser: Napoli, Alessandro, Obeid, Iyad
Format: Artikel
Sprache:eng
Schlagworte:
Action Potentials - physiology
Animals
Biological Evolution
Brain - physiology
Cells, Cultured
Computer Simulation
Electric Stimulation - methods
Humans
MEA
Microelectrodes
Nerve Net - physiology
Neurology
Neuronal Plasticity - physiology
Plasticity
Rat
Rats
Rats, Sprague-Dawley
Tissue Array Analysis - instrumentation
Tissue Array Analysis - methods
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Beschreibung
Zusammenfassung:Highlights • This work investigates plasticity in dissociated neuronal cultures on MEA grids. • Network response was measured after stimulating different grid quadrants. • There were no spatial differences in the stimulus-evoked activity within quadrants. • Depression was observed but decreased over time, suggesting habituation.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2015.10.002