miR-190a inhibits epithelial–mesenchymal transition of hepatoma cells via targeting the long non-coding RNA treRNA
•We identified a novel layer of treRNA regulation.•miR-190a inhibits hepatoma migration and invasion by silencing of treRNA.•miR-190a negatively regulates treRNA as a tumor suppressor in hepatoma. treRNA is a long non-coding RNA (lncRNA) involved in cancer progression. In this study, we show that mi...
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| Veröffentlicht in: | FEBS letters 2015-12, Vol.589 (24), p.4079-4087 |
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| creator | Wang, Xinyu Ren, Yanli Yang, Xinyu Xiong, Xiangyu Han, Sichong Ge, Yunxia Pan, Wenting Zhou, Liqing Yuan, Qipeng Yang, Ming |
| description | •We identified a novel layer of treRNA regulation.•miR-190a inhibits hepatoma migration and invasion by silencing of treRNA.•miR-190a negatively regulates treRNA as a tumor suppressor in hepatoma.
treRNA is a long non-coding RNA (lncRNA) involved in cancer progression. In this study, we show that miR-190a can silence treRNA post-transcriptionally. Suppression of treRNA by miR-190a led to significant changes of mesenchymal–epithelial transition markers and impaired migration and invasion capability of hepatoma cells. TCGA data indicated that miR-190a exhibited lower expression in hepatoma tissues, especially from patients with vascular tumor invasion, compared to normal tissues. Our results reveal the involvement of miR-190a–treRNA axis in hepatoma progression and shed light on lncRNA-based cancer therapies for hepatoma patients at high risk of metastasis. |
| doi_str_mv | 10.1016/j.febslet.2015.11.024 |
| format | Article |
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treRNA is a long non-coding RNA (lncRNA) involved in cancer progression. In this study, we show that miR-190a can silence treRNA post-transcriptionally. Suppression of treRNA by miR-190a led to significant changes of mesenchymal–epithelial transition markers and impaired migration and invasion capability of hepatoma cells. TCGA data indicated that miR-190a exhibited lower expression in hepatoma tissues, especially from patients with vascular tumor invasion, compared to normal tissues. Our results reveal the involvement of miR-190a–treRNA axis in hepatoma progression and shed light on lncRNA-based cancer therapies for hepatoma patients at high risk of metastasis.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/j.febslet.2015.11.024</identifier><identifier>PMID: 26608035</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Binding Sites ; Biomarkers - metabolism ; Carcinoma, Hepatocellular - metabolism ; Carcinoma, Hepatocellular - pathology ; Cell Line, Tumor ; Cell Movement ; Down-Regulation ; Epithelial-Mesenchymal Transition ; Epithelial-to-mesenchymal transition ; Gene Expression Regulation, Neoplastic ; Genes, Reporter ; Hepatoma ; Humans ; Liver - metabolism ; Liver - pathology ; Liver Neoplasms - metabolism ; Liver Neoplasms - pathology ; Long non-coding RNA ; MicroRNAs - metabolism ; miR-190a ; Mutation ; Neoplasm Invasiveness ; RNA - antagonists & inhibitors ; RNA - metabolism ; RNA Interference ; RNA, Long Noncoding - antagonists & inhibitors ; RNA, Long Noncoding - metabolism ; RNA, Neoplasm - metabolism ; RNA, Small Interfering ; Translation regulatory long non-coding RNA</subject><ispartof>FEBS letters, 2015-12, Vol.589 (24), p.4079-4087</ispartof><rights>2015 Federation of European Biochemical Societies</rights><rights>FEBS Letters 589 (2015) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><rights>Copyright © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5105-60b537f35f97d52eddd3050a0e060a6577aa1d84f7bb664c8f23c9e49cea8a613</citedby><cites>FETCH-LOGICAL-c5105-60b537f35f97d52eddd3050a0e060a6577aa1d84f7bb664c8f23c9e49cea8a613</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2Fj.febslet.2015.11.024$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.febslet.2015.11.024$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,1417,1433,3550,27924,27925,45574,45575,45995,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26608035$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Xinyu</creatorcontrib><creatorcontrib>Ren, Yanli</creatorcontrib><creatorcontrib>Yang, Xinyu</creatorcontrib><creatorcontrib>Xiong, Xiangyu</creatorcontrib><creatorcontrib>Han, Sichong</creatorcontrib><creatorcontrib>Ge, Yunxia</creatorcontrib><creatorcontrib>Pan, Wenting</creatorcontrib><creatorcontrib>Zhou, Liqing</creatorcontrib><creatorcontrib>Yuan, Qipeng</creatorcontrib><creatorcontrib>Yang, Ming</creatorcontrib><title>miR-190a inhibits epithelial–mesenchymal transition of hepatoma cells via targeting the long non-coding RNA treRNA</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>•We identified a novel layer of treRNA regulation.•miR-190a inhibits hepatoma migration and invasion by silencing of treRNA.•miR-190a negatively regulates treRNA as a tumor suppressor in hepatoma.
treRNA is a long non-coding RNA (lncRNA) involved in cancer progression. In this study, we show that miR-190a can silence treRNA post-transcriptionally. Suppression of treRNA by miR-190a led to significant changes of mesenchymal–epithelial transition markers and impaired migration and invasion capability of hepatoma cells. TCGA data indicated that miR-190a exhibited lower expression in hepatoma tissues, especially from patients with vascular tumor invasion, compared to normal tissues. Our results reveal the involvement of miR-190a–treRNA axis in hepatoma progression and shed light on lncRNA-based cancer therapies for hepatoma patients at high risk of metastasis.</description><subject>Binding Sites</subject><subject>Biomarkers - metabolism</subject><subject>Carcinoma, Hepatocellular - metabolism</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Cell Line, Tumor</subject><subject>Cell Movement</subject><subject>Down-Regulation</subject><subject>Epithelial-Mesenchymal Transition</subject><subject>Epithelial-to-mesenchymal transition</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Genes, Reporter</subject><subject>Hepatoma</subject><subject>Humans</subject><subject>Liver - metabolism</subject><subject>Liver - pathology</subject><subject>Liver Neoplasms - metabolism</subject><subject>Liver Neoplasms - pathology</subject><subject>Long non-coding RNA</subject><subject>MicroRNAs - metabolism</subject><subject>miR-190a</subject><subject>Mutation</subject><subject>Neoplasm Invasiveness</subject><subject>RNA - antagonists & inhibitors</subject><subject>RNA - metabolism</subject><subject>RNA Interference</subject><subject>RNA, Long Noncoding - antagonists & inhibitors</subject><subject>RNA, Long Noncoding - metabolism</subject><subject>RNA, Neoplasm - metabolism</subject><subject>RNA, Small Interfering</subject><subject>Translation regulatory long non-coding RNA</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc9u1DAQhy0EokvhEUA-ckkYx_GfnFCpWlqpAqnA2XKcSderJF5ib6u98Q68IU9SR7twpaexrd98M_JHyFsGJQMmP2zKHts4YCorYKJkrISqfkZWTCte8Frq52QFwOpCqIafkFcxbiDfNWtekpNKStDAxYqk0d8WrAFL_bT2rU-R4tanNQ7eDn9-_R4x4uTW-9EONM12ij75MNHQ0zVubQqjpQ6HIdJ7b2my8x0mP93RDKBDyIcpTIUL3fJ2--UsIzCX1-RFb4eIb471lPy4vPh-flXcfP18fX52UzjBQBQSWsFVz0XfqE5U2HUdBwEWECRYKZSylnW67lXbSlk73VfcNVg3Dq22kvFT8v7A3c7h5w5jMqOPy7p2wrCLhilZccXVk6KC1VoDgxwVh6ibQ4wz9mY7-9HOe8PALG7MxhzdmMWNYcxkN7nv3XHErh2x-9f1V0YOXB0CD37A_dOo5vLiU_VtEb14ZiIvWOkF9fGAwvy99x5nE53PIrHzM7pkuuD_s-0jjR-47Q</recordid><startdate>20151221</startdate><enddate>20151221</enddate><creator>Wang, Xinyu</creator><creator>Ren, Yanli</creator><creator>Yang, Xinyu</creator><creator>Xiong, Xiangyu</creator><creator>Han, Sichong</creator><creator>Ge, Yunxia</creator><creator>Pan, Wenting</creator><creator>Zhou, Liqing</creator><creator>Yuan, Qipeng</creator><creator>Yang, Ming</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TM</scope></search><sort><creationdate>20151221</creationdate><title>miR-190a inhibits epithelial–mesenchymal transition of hepatoma cells via targeting the long non-coding RNA treRNA</title><author>Wang, Xinyu ; Ren, Yanli ; Yang, Xinyu ; Xiong, Xiangyu ; Han, Sichong ; Ge, Yunxia ; Pan, Wenting ; Zhou, Liqing ; Yuan, Qipeng ; Yang, Ming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5105-60b537f35f97d52eddd3050a0e060a6577aa1d84f7bb664c8f23c9e49cea8a613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Binding Sites</topic><topic>Biomarkers - metabolism</topic><topic>Carcinoma, Hepatocellular - metabolism</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Cell Line, Tumor</topic><topic>Cell Movement</topic><topic>Down-Regulation</topic><topic>Epithelial-Mesenchymal Transition</topic><topic>Epithelial-to-mesenchymal transition</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Genes, Reporter</topic><topic>Hepatoma</topic><topic>Humans</topic><topic>Liver - metabolism</topic><topic>Liver - pathology</topic><topic>Liver Neoplasms - metabolism</topic><topic>Liver Neoplasms - pathology</topic><topic>Long non-coding RNA</topic><topic>MicroRNAs - metabolism</topic><topic>miR-190a</topic><topic>Mutation</topic><topic>Neoplasm Invasiveness</topic><topic>RNA - antagonists & inhibitors</topic><topic>RNA - metabolism</topic><topic>RNA Interference</topic><topic>RNA, Long Noncoding - antagonists & inhibitors</topic><topic>RNA, Long Noncoding - metabolism</topic><topic>RNA, Neoplasm - metabolism</topic><topic>RNA, Small Interfering</topic><topic>Translation regulatory long non-coding RNA</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Xinyu</creatorcontrib><creatorcontrib>Ren, Yanli</creatorcontrib><creatorcontrib>Yang, Xinyu</creatorcontrib><creatorcontrib>Xiong, Xiangyu</creatorcontrib><creatorcontrib>Han, Sichong</creatorcontrib><creatorcontrib>Ge, Yunxia</creatorcontrib><creatorcontrib>Pan, Wenting</creatorcontrib><creatorcontrib>Zhou, Liqing</creatorcontrib><creatorcontrib>Yuan, Qipeng</creatorcontrib><creatorcontrib>Yang, Ming</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Nucleic Acids Abstracts</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Xinyu</au><au>Ren, Yanli</au><au>Yang, Xinyu</au><au>Xiong, Xiangyu</au><au>Han, Sichong</au><au>Ge, Yunxia</au><au>Pan, Wenting</au><au>Zhou, Liqing</au><au>Yuan, Qipeng</au><au>Yang, Ming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>miR-190a inhibits epithelial–mesenchymal transition of hepatoma cells via targeting the long non-coding RNA treRNA</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>2015-12-21</date><risdate>2015</risdate><volume>589</volume><issue>24</issue><spage>4079</spage><epage>4087</epage><pages>4079-4087</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>•We identified a novel layer of treRNA regulation.•miR-190a inhibits hepatoma migration and invasion by silencing of treRNA.•miR-190a negatively regulates treRNA as a tumor suppressor in hepatoma.
treRNA is a long non-coding RNA (lncRNA) involved in cancer progression. In this study, we show that miR-190a can silence treRNA post-transcriptionally. Suppression of treRNA by miR-190a led to significant changes of mesenchymal–epithelial transition markers and impaired migration and invasion capability of hepatoma cells. TCGA data indicated that miR-190a exhibited lower expression in hepatoma tissues, especially from patients with vascular tumor invasion, compared to normal tissues. Our results reveal the involvement of miR-190a–treRNA axis in hepatoma progression and shed light on lncRNA-based cancer therapies for hepatoma patients at high risk of metastasis.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>26608035</pmid><doi>10.1016/j.febslet.2015.11.024</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | FEBS letters, 2015-12, Vol.589 (24), p.4079-4087 |
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| source | MEDLINE; Wiley Free Content; ScienceDirect Journals (5 years ago - present); EZB-FREE-00999 freely available EZB journals; Wiley Online Library All Journals; Alma/SFX Local Collection |
| subjects | Binding Sites Biomarkers - metabolism Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Line, Tumor Cell Movement Down-Regulation Epithelial-Mesenchymal Transition Epithelial-to-mesenchymal transition Gene Expression Regulation, Neoplastic Genes, Reporter Hepatoma Humans Liver - metabolism Liver - pathology Liver Neoplasms - metabolism Liver Neoplasms - pathology Long non-coding RNA MicroRNAs - metabolism miR-190a Mutation Neoplasm Invasiveness RNA - antagonists & inhibitors RNA - metabolism RNA Interference RNA, Long Noncoding - antagonists & inhibitors RNA, Long Noncoding - metabolism RNA, Neoplasm - metabolism RNA, Small Interfering Translation regulatory long non-coding RNA |
| title | miR-190a inhibits epithelial–mesenchymal transition of hepatoma cells via targeting the long non-coding RNA treRNA |
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