miR-190a inhibits epithelial–mesenchymal transition of hepatoma cells via targeting the long non-coding RNA treRNA

•We identified a novel layer of treRNA regulation.•miR-190a inhibits hepatoma migration and invasion by silencing of treRNA.•miR-190a negatively regulates treRNA as a tumor suppressor in hepatoma. treRNA is a long non-coding RNA (lncRNA) involved in cancer progression. In this study, we show that mi...

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Veröffentlicht in:FEBS letters 2015-12, Vol.589 (24), p.4079-4087
Hauptverfasser: Wang, Xinyu, Ren, Yanli, Yang, Xinyu, Xiong, Xiangyu, Han, Sichong, Ge, Yunxia, Pan, Wenting, Zhou, Liqing, Yuan, Qipeng, Yang, Ming
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Sprache:eng
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Zusammenfassung:•We identified a novel layer of treRNA regulation.•miR-190a inhibits hepatoma migration and invasion by silencing of treRNA.•miR-190a negatively regulates treRNA as a tumor suppressor in hepatoma. treRNA is a long non-coding RNA (lncRNA) involved in cancer progression. In this study, we show that miR-190a can silence treRNA post-transcriptionally. Suppression of treRNA by miR-190a led to significant changes of mesenchymal–epithelial transition markers and impaired migration and invasion capability of hepatoma cells. TCGA data indicated that miR-190a exhibited lower expression in hepatoma tissues, especially from patients with vascular tumor invasion, compared to normal tissues. Our results reveal the involvement of miR-190a–treRNA axis in hepatoma progression and shed light on lncRNA-based cancer therapies for hepatoma patients at high risk of metastasis.
ISSN:0014-5793
1873-3468
DOI:10.1016/j.febslet.2015.11.024