Baculovirus vectors expressing F proteins in combination with virus-induced signaling adaptor (VISA) molecules confer protection against respiratory syncytial virus infection

Highlights • We constructed recombinant baculoviruses (rBVs) expressing RSV F proteins. • Bac-CF/tF64 induced mixed Th1/Th2 cytokine responses with reduced immunopathology. • Co-expression of VISA reduced Th2 cytokines production induced by Bac-CF/tF64. • Co-expression of VISA relieved pathology of...

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Veröffentlicht in:	Vaccine 2016-01, Vol.34 (2), p.252-260
Hauptverfasser:	Zhang, Yuan, Qiao, Lei, Hu, Xiao, Zhao, Kang, Zhang, Yanwen, Chai, Feng, Pan, Zishu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - immunology Allergy and Immunology Animals Antibodies, Neutralizing - blood Antibodies, Viral - blood Baculoviridae - genetics Baculovirus Cloning Cytokines Cytokines - secretion F protein Female Genetic Vectors Immunoglobulin G - blood Immunoglobulins Infections Mammals Mice, Inbred BALB C Microscopy Plasmids Proteins Respiratory syncytial virus Respiratory Syncytial Virus Infections - prevention & control Respiratory Syncytial Virus Vaccines - administration & dosage Respiratory Syncytial Virus Vaccines - genetics Respiratory Syncytial Virus Vaccines - immunology Sf9 Cells Vaccine Vaccines Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - genetics Vaccines, Synthetic - immunology Viral Fusion Proteins - genetics Viral Fusion Proteins - immunology VISA
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Zusammenfassung:	Highlights • We constructed recombinant baculoviruses (rBVs) expressing RSV F proteins. • Bac-CF/tF64 induced mixed Th1/Th2 cytokine responses with reduced immunopathology. • Co-expression of VISA reduced Th2 cytokines production induced by Bac-CF/tF64. • Co-expression of VISA relieved pathology of vaccinated mice upon RSV challenge.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2015.11.027