Contradicting roles of miR-182 in both NK cells and their host target hepatocytes in HCV

Highlights • miR-182 has dys-regulated expression in both NK cells and liver biopsies of HCV infected patients. • miR-182 and its inhibitor enhanced NK cell of HCV infected patients against HCV infected Huh7 cells. • miR-182 decreases ULBP-2 levels in HCV infected Huh7 cells and increase their viral...

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Veröffentlicht in:	Immunology letters 2016-01, Vol.169, p.52-60
Hauptverfasser:	El Sobky, Shereen A, El-Ekiaby, Nada M, Mekky, Radwa Y, Elemam, Noha M, Mohey Eldin, Mohammad A, El-sayed, Mohammed, Esmat, Gamal, Abdelaziz, Ahmed I
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Cell Line Epigenesis, Genetic Gene Expression Regulation GPI-Linked Proteins - genetics GPI-Linked Proteins - metabolism HCV Hepacivirus - physiology Hepatitis C - genetics Hepatitis C - immunology Hepatitis C virus Hepatocytes - physiology Hepatocytes - virology Host Specificity Humans Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Killer Cells, Natural - physiology Killer Cells, Natural - virology Lymphocyte Activation MicroRNAs - genetics MicroRNAs - metabolism miR‑182 Natural killer cells NK Cell Lectin-Like Receptor Subfamily C - genetics NK Cell Lectin-Like Receptor Subfamily C - metabolism NK Cell Lectin-Like Receptor Subfamily K - genetics NK Cell Lectin-Like Receptor Subfamily K - metabolism NKG2A NKG2D Organ Specificity ULBP2 Viral Load Virus Replication
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Zusammenfassung:	Highlights • miR-182 has dys-regulated expression in both NK cells and liver biopsies of HCV infected patients. • miR-182 and its inhibitor enhanced NK cell of HCV infected patients against HCV infected Huh7 cells. • miR-182 decreases ULBP-2 levels in HCV infected Huh7 cells and increase their viral load.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2015.10.013