Synthesis of Antifungal Evaluation of 2H-[1,2,3]Triazolo[4,5-g]isoquinoline-4,9-diones

Synthesis of Antifungal Evaluation of 2H-[1,2,3]Triazolo[4,5-g]isoquinoline-4,9-diones

2H-[1,2,3]Triazolo[4,5-g]isoquinoline-4,9-diones and 2H-[1,2,3]triazolo[4,5-g]quinoline-4,9-diones were synthesized and tested for in vitro antifungal activity against pathogenic fungi. Many of those synthesized showed potent antifungal activity. Compounds 3a, 3b, 3g, and 3h completely inhibited the...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemical & pharmaceutical bulletin 2014/11/01, Vol.62(11), pp.1119-1124
Hauptverfasser: Ryu, Chung-Kyu, Oh, Sun Young, Choi, Soo Jung, Kang, Da Young
Format: Artikel
Sprache:eng
Schlagworte:
2H-[1,2,3]triazolo[4,5-g]isoquinoline-4,9-dione
antifungal
Antifungal Agents - chemical synthesis
Antifungal Agents - chemistry
Antifungal Agents - pharmacology
antimicrobial
Drug Design
Fungi - drug effects
fungus
Humans
Isoquinolines - chemical synthesis
Isoquinolines - chemistry
Isoquinolines - pharmacology
Microbial Sensitivity Tests
Mycoses - drug therapy
Structure-Activity Relationship
Triazoles - chemical synthesis
Triazoles - chemistry
Triazoles - pharmacology
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:2H-[1,2,3]Triazolo[4,5-g]isoquinoline-4,9-diones and 2H-[1,2,3]triazolo[4,5-g]quinoline-4,9-diones were synthesized and tested for in vitro antifungal activity against pathogenic fungi. Many of those synthesized showed potent antifungal activity. Compounds 3a, 3b, 3g, and 3h completely inhibited the growth of all fungal species tested at the MIC level of 0.8–12.5 µg/mL. The results suggest that 2H-[1,2,3]triazolo[4,5-g]isoquinoline-4,9-diones could be antifungal agents.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.c14-00527