The frequency of spontaneous seizures in rats correlates with alterations in sensorimotor gating, spatial working memory, and parvalbumin expression throughout limbic regions

Highlights • Cognitive and sensorimotor symptoms are correlated with seizure frequency. • Dysfunctions in prefrontal-associated circuits might explain interictal disorders. • Lithium–pilocarpine model reproduces comorbidities of temporal lobe epilepsy.

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Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2016-01, Vol.312, p.86-98
Hauptverfasser:	Wolf, D.C, Bueno-Júnior, L.S, Lopes-Aguiar, C, Do Val Da Silva, R.A, Kandratavicius, L, Leite, J.P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavior, Animal - physiology Disease Models, Animal Epilepsy, Temporal Lobe - chemically induced Epilepsy, Temporal Lobe - metabolism Epilepsy, Temporal Lobe - physiopathology Limbic System - metabolism Limbic System - physiopathology Lithium - pharmacology lithium–pilocarpine Male Memory, Short-Term - physiology Muscarinic Agonists - pharmacology Neurology parvalbumin immunohistochemistry Parvalbumins - metabolism Pilocarpine - pharmacology Prefrontal Cortex - physiopathology prepulse inhibition psychiatric comorbidities radial maze Rats Rats, Wistar Seizures - chemically induced Seizures - metabolism Seizures - physiopathology Sensory Gating - physiology Spatial Memory - physiology temporal lobe epilepsy
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Beschreibung
Zusammenfassung:	Highlights • Cognitive and sensorimotor symptoms are correlated with seizure frequency. • Dysfunctions in prefrontal-associated circuits might explain interictal disorders. • Lithium–pilocarpine model reproduces comorbidities of temporal lobe epilepsy.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.11.008